AA560

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571274

CAS#: 65372-80-7

Description: AA560 is a nonsteroidal antiandrogen. AA560 decreases the uptake of 3H-androgens in the ventral prostate. AA560 decreases the weight of accessory organs.


Price and Availability

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Price

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AA560 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571274
Name: AA560
CAS#: 65372-80-7
Chemical Formula: C10H10Cl3NO2
Exact Mass: 280.9777
Molecular Weight: 282.55
Elemental Analysis: C, 42.51; H, 3.57; Cl, 37.64; N, 4.96; O, 11.32


Synonym: AA560; AA-560; AA 560

IUPAC/Chemical Name: Propanamide, 2-hydroxy-2-methyl-N-(3,4,5-trichlorophenyl)-

InChi Key: FVEPMRZJQUYLRA-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H10Cl3NO2/c1-10(2,16)9(15)14-5-3-6(11)8(13)7(12)4-5/h3-4,16H,1-2H3,(H,14,15)

SMILES Code: CC(C)(O)C(NC1=CC(Cl)=C(Cl)C(Cl)=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shida K, Yamanaka H, Koya A, Wakabayashi K, Mori H, Shibata K, Shimazawa E. Action of a novel nonsteroidal antiandrogen, AA560. Endocrinol Jpn. 1980 Feb;27(1):69-76. PubMed PMID: 6156070.

2: Yoshida M, Asano M, Kaetsu I, Yamanaka H, Nakai K, Yuasa H, Shida K. Effect of drug-vinyl copolymer delivery composites on the rat prostate. J Biomed Mater Res. 1985 Jul-Aug;19(6):615-29. PubMed PMID: 2416759.

3: Imai K, Takahashi O, Watanabe K, Nakazawa Y, Nakata S, Yamanaka H. [The effects of antiprostatic agents on the accessory sex organs of rats treated with adrenal androgens]. Hinyokika Kiyo. 1991 Dec;37(12):1669-76. Japanese. PubMed PMID: 1785391.

4: Yamanaka H, Koya A, Imai K, Nakai K, Yuasa H, Sugiyama Y, Shida K, Wakabayashi K. Effect of AA560 (a nonsteroidal antiandrogen) implantation in the hypothalamus on gonadotropin secretion in male rats. Endocrinol Jpn. 1981 Dec;28(6):819-22. PubMed PMID: 6809452.

5: Kim SY, Song KA, Kieff E, Kang MS. Small molecule and peptide-mediated inhibition of Epstein-Barr virus nuclear antigen 1 dimerization. Biochem Biophys Res Commun. 2012 Jul 27;424(2):251-6. doi: 10.1016/j.bbrc.2012.06.095. Epub 2012 Jun 23. PubMed PMID: 22735264.

6: Imai K, Watanabe K, Takahashi O, Shimizu N, Nakata S, Kawashima K, Suzuki T, Yamanaka H. [A study of the androgenic activity of anti-androgen]. Nihon Naibunpi Gakkai Zasshi. 1990 Jun 20;66(6):597-606. Japanese. PubMed PMID: 1696915.

7: Takahashi O, Imai K, Watanabe K, Nakazawa Y, Nakata S, Kurita M, Saito Y, Kubota H, Yamanaka H. [The effect of sodium-4-[2-(2,3-dimethyl-4-[1-(4- isobutylphenyl)ethoxy]benzolamino)phenoxy] butyrate (ONO-3805) and antiandrogenic agents on the rat accessory sex organs]. Hinyokika Kiyo. 1992 Mar;38(3):305-10. Japanese. PubMed PMID: 1381863.

8: Lapierre H, Doepel L, Milne E, Lobley GE. Responses in mammary and splanchnic metabolism to altered lysine supply in dairy cows. Animal. 2009 Mar;3(3):360-71. doi: 10.1017/S1751731108003571. PubMed PMID: 22444306.

9: Anand SS, Murthy SN, Vaidya VS, Mumtaz MM, Mehendale HM. Tissue repair plays pivotal role in final outcome of liver injury following chloroform and allyl alcohol binary mixture. Food Chem Toxicol. 2003 Aug;41(8):1123-32. PubMed PMID: 12842180.

10: Britt WJ, Jarvis MA, Drummond DD, Mach M. Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein B. J Virol. 2005 Apr;79(7):4066-79. PubMed PMID: 15767408; PubMed Central PMCID: PMC1061566.

11: Yamanaka H, Matsuoka M, Yuasa H, Koya A, Imai K, Ebihara K, Nakai K, Shida K. Effects of antiprostatic agents on 5alpha-dihydrotestosterone binding to rat hypophyseal and hypothalamic cytosol macromolecules. Endocrinol Jpn. 1979 Feb;26(1):97-102. PubMed PMID: 86441.

12: Benvenga S, Bartolone L, Trimarchi F. Thyroid iodide transporter: local sequence homologies with thyroid autoantigens. J Endocrinol Invest. 1997 Oct;20(9):508-12. PubMed PMID: 9413803.

13: Suzuki T, Horibe I, Uchida N, Ezumi K, Uchida K, Takeda K, Tanaka A, Nishizawa Y, Matsumoto K. Effects of antiandrogens on growth of androgen-dependent mouse mammary tumor (Shionogi carcinoma 115) in vivo and in vitro. J Steroid Biochem Mol Biol. 1990 Nov 30;37(4):559-67. PubMed PMID: 2278840.