A 68828

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571270

CAS#: 13209-52-5

Description: A 68828 is an atrial natriuretic factor analog. It improves renal function and reduces tissue damage.


Price and Availability

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A 68828 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571270
Name: A 68828
CAS#: 13209-52-5
Chemical Formula: C68H116N26O15S2
Exact Mass: 1600.8555
Molecular Weight: 1601.963
Elemental Analysis: C, 50.98; H, 7.30; N, 22.73; O, 14.98; S, 4.00


Synonym: A 68828; A-68828; A68828

IUPAC/Chemical Name: (6S,9R,13R,16S,19S,22S,25S,28S)-1,6-diamino-28-((2S,5S,14S,Z)-14-amino-2-((S)-sec-butyl)-15-cyclohexyl-5-(3-guanidinopropyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadec-11-enamido)-19-benzyl-22-((S)-sec-butyl)-16,25-bis(3-guanidinopropyl)-1-imino-9,13-bis(mercaptomethyl)-7,10,12,15,18,21,24,27-octaoxo-2,8,11,14,17,20,23,26-octaazatriacontan-30-oic acid

InChi Key: HCJNLCHEKMAIHX-PVCRQNKGSA-N

InChi Code: InChI=1S/C68H116N26O15S2/c1-5-36(3)52(63(108)88-45(30-39-19-11-8-12-20-39)59(104)86-43(23-15-27-81-67(75)76)56(101)91-48(35-111)62(107)94-61(106)47(34-110)90-55(100)40(69)21-13-25-79-65(71)72)93-58(103)44(24-16-28-82-68(77)78)87-60(105)46(31-51(97)98)89-64(109)53(37(4)6-2)92-57(102)42(22-14-26-80-66(73)74)85-50(96)33-83-49(95)32-84-54(99)41(70)29-38-17-9-7-10-18-38/h8,11-12,19-20,32,36-38,40-48,52-53,110-111H,5-7,9-10,13-18,21-31,33-35,69-70H2,1-4H3,(H,83,95)(H,85,96)(H,86,104)(H,87,105)(H,88,108)(H,89,109)(H,90,100)(H,91,101)(H,92,102)(H,93,103)(H,97,98)(H4,71,72,79)(H4,73,74,80)(H4,75,76,81)(H4,77,78,82)(H,94,106,107)/b84-32-/t36-,37-,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-,53-/m0/s1

SMILES Code: CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(/C=N\C([C@@H](N)CC1CCCCC1)=O)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC(O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CS)=O)=O)CS)=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Pollock DM, Opgenorth TJ. Beneficial effect of the atrial natriuretic factor analog A68828 in postischemic acute renal failure. J Pharmacol Exp Ther. 1990 Dec;255(3):1166-9. PubMed PMID: 2148187.

2: Pollock DM, Opgenorth TJ. Beneficial effect of the ANF analog A68828 on recovery from ischemic acute renal failure. Ren Fail. 1992;14(2):141-6. PubMed PMID: 1386156.

3: Deegan PM, Ryan MP, Basinger MA, Jones MM, Hande KR. Protection from cisplatin nephrotoxicity by A68828, an atrial natriuretic peptide. Ren Fail. 1995 Mar;17(2):117-23. PubMed PMID: 7644762.

4: Pollock DM, Holst M, Opgenorth TJ. Effect of the ANF analog A68828 in cisplatin-induced acute renal failure. J Pharmacol Exp Ther. 1991 Jun;257(3):1179-83. PubMed PMID: 1828504.

5: Devine EM Jr, Buko AM, Cepa SP, Davidsen SK, Holleman WH, Marselle CA, Opgenorth TJ, Rockway TW, von Geldern TW. HPLC and PDMS analysis of cleavage products aid in the design of small, stable ANP analogues. Int J Pept Protein Res. 1992 Dec;40(6):532-7. PubMed PMID: 1286937.

6: von Geldern TW, Rockway TW, Davidsen SK, Budzik GP, Bush EN, Chu-Moyer MY, Devine EM Jr, Holleman WH, Johnson MC, Lucas SD, et al. Small atrial natriuretic peptide analogues: design, synthesis, and structural requirements for guanylate cyclase activation. J Med Chem. 1992 Mar 6;35(5):808-16. PubMed PMID: 1347790.

7: Pollock DM, Opgenorth TJ. Atrial natriuretic peptides in the treatment of acute renal failure. Ren Fail. 1993;15(4):439-49. Review. PubMed PMID: 8210557.

8: Holleman WH, Budzik GP, Devine EM, Pollock DM, Opgenorth TJ, Thomas AM, von Geldern TW, Rockway TW. Truncated atrial natriuretic factor analogs retain full agonist activity. Can J Physiol Pharmacol. 1991 Oct;69(10):1622-7. PubMed PMID: 1663820.