Baicalein
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561385

CAS#: 491-67-8

Description: Baicalein is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors. Baicalein is also an antagonist of the estrogen receptor.


Price and Availability

Size
Price

1g
USD 255
Size
Price

5g
USD 590
Size
Price

Baicalein, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 561385
Name: Baicalein
CAS#: 491-67-8
Chemical Formula: C15H10O5
Exact Mass: 270.0528
Molecular Weight: 270.24
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60


Synonym: Baicalein; BaiKalein; Noroxylin;

IUPAC/Chemical Name: 5,6,7-Trihydroxy-2-phenylchromen-4-one

InChi Key: FXNFHKRTJBSTCS-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

SMILES Code: O=C1C=C(C2=CC=CC=C2)OC3=C1C(O)=C(O)C(O)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bie B, Sun J, Guo Y, Li J, Jiang W, Yang J, Huang C, Li Z. Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma. Biomed Pharmacother. 2017 Sep;93:1285-1291. doi: 10.1016/j.biopha.2017.07.068. Review. PubMed PMID: 28747003.

2: Gong D, Hong Y, Sun G, Zhang J. Novel strategy for quality consistency evaluation of Chinese medicine "YIQING" tablet that combines the simultaneous quantification and screening of ten bioactive constituents. J Sep Sci. 2017 Aug;40(15):3064-3073. doi: 10.1002/jssc.201700291. Epub 2017 Jun 28. Review. PubMed PMID: 28590083.

3: Davatgaran-Taghipour Y, Masoomzadeh S, Farzaei MH, Bahramsoltani R, Karimi-Soureh Z, Rahimi R, Abdollahi M. Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective. Int J Nanomedicine. 2017 Apr 4;12:2689-2702. doi: 10.2147/IJN.S131973. eCollection 2017. Review. PubMed PMID: 28435252; PubMed Central PMCID: PMC5388197.

4: Dinda B, Dinda S, DasSharma S, Banik R, Chakraborty A, Dinda M. Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. Eur J Med Chem. 2017 May 5;131:68-80. doi: 10.1016/j.ejmech.2017.03.004. Epub 2017 Mar 6. Review. PubMed PMID: 28288320.

5: Li LC, Kan LD. Traditional Chinese medicine for pulmonary fibrosis therapy: Progress and future prospects. J Ethnopharmacol. 2017 Feb 23;198:45-63. doi: 10.1016/j.jep.2016.12.042. Epub 2016 Dec 28. Review. PubMed PMID: 28038955.

6: Wu J, Hu Y, Xiang L, Li S, Yuan Y, Chen X, Zhang Y, Huang W, Meng X, Wang P. San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review. Front Pharmacol. 2016 Nov 28;7:448. eCollection 2016. Review. PubMed PMID: 27965575; PubMed Central PMCID: PMC5124576.

7: Gong WY, Zhao ZX, Liu BJ, Lu LW, Dong JC. Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors. Eur J Med Chem. 2017 Jan 27;126:844-852. doi: 10.1016/j.ejmech.2016.11.058. Epub 2016 Dec 1. Review. PubMed PMID: 27960146.

8: Park S. Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids. Molecules. 2016 Nov 16;21(11). pii: E1556. Review. PubMed PMID: 27854350.

9: Liu H, Dong Y, Gao Y, Du Z, Wang Y, Cheng P, Chen A, Huang H. The Fascinating Effects of Baicalein on Cancer: A Review. Int J Mol Sci. 2016 Oct 9;17(10). pii: E1681. Review. PubMed PMID: 27735841; PubMed Central PMCID: PMC5085714.

10: Noh K, Kang Y, Nepal MR, Jeong KS, Oh DG, Kang MJ, Lee S, Kang W, Jeong HG, Jeong TC. Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics. Molecules. 2016 Mar 10;21(3):337. doi: 10.3390/molecules21030337. Review. PubMed PMID: 26978333.

11: Liu-Smith F, Meyskens FL. Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma. Mol Nutr Food Res. 2016 Jun;60(6):1264-74. doi: 10.1002/mnfr.201500822. Epub 2016 Mar 21. Review. PubMed PMID: 26865001; PubMed Central PMCID: PMC4900912.

12: Yarla NS, Bishayee A, Sethi G, Reddanna P, Kalle AM, Dhananjaya BL, Dowluru KS, Chintala R, Duddukuri GR. Targeting arachidonic acid pathway by natural products for cancer prevention and therapy. Semin Cancer Biol. 2016 Oct;40-41:48-81. doi: 10.1016/j.semcancer.2016.02.001. Epub 2016 Feb 4. Review. PubMed PMID: 26853158.

13: Moosavi F, Hosseini R, Saso L, Firuzi O. Modulation of neurotrophic signaling pathways by polyphenols. Drug Des Devel Ther. 2015 Dec 21;10:23-42. doi: 10.2147/DDDT.S96936. eCollection 2016. Review. PubMed PMID: 26730179; PubMed Central PMCID: PMC4694682.

14: de Oliveira MR, Nabavi SF, Habtemariam S, Erdogan Orhan I, Daglia M, Nabavi SM. The effects of baicalein and baicalin on mitochondrial function and dynamics: A review. Pharmacol Res. 2015 Oct;100:296-308. doi: 10.1016/j.phrs.2015.08.021. Epub 2015 Aug 28. Review. PubMed PMID: 26318266.

15: Zhang H, Zhai J, Zhang L, Li C, Zhao Y, Chen Y, Li Q, Hu XP. In Vitro Inhibition of Glyoxalase І by Flavonoids: New Insights from Crystallographic Analysis. Curr Top Med Chem. 2016;16(4):460-6. Review. PubMed PMID: 26268338.

16: Fajardo AM, Piazza GA. Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G59-70. doi: 10.1152/ajpgi.00101.2014. Epub 2015 May 28. Review. PubMed PMID: 26021807; PubMed Central PMCID: PMC4504955.

17: Dinda B, SilSarma I, Dinda M, Rudrapaul P. Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation. J Ethnopharmacol. 2015 Feb 23;161:255-78. doi: 10.1016/j.jep.2014.12.027. Epub 2014 Dec 25. Review. PubMed PMID: 25543018.

18: Kim DH, Sung B, Chung HY, Kim ND. Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine. J Cancer Prev. 2014 Sep;19(3):153-60. doi: 10.15430/JCP.2014.19.3.153. Review. PubMed PMID: 25337584; PubMed Central PMCID: PMC4189507.

19: Xiao JR, Do CW, To CH. Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. J Ocul Pharmacol Ther. 2014 Oct;30(8):605-14. doi: 10.1089/jop.2014.0074. Review. PubMed PMID: 25280175.

20: Chen H, Gao Y, Wu J, Chen Y, Chen B, Hu J, Zhou J. Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies. Cancer Lett. 2014 Nov 1;354(1):5-11. doi: 10.1016/j.canlet.2014.08.003. Epub 2014 Aug 13. Review. PubMed PMID: 25128647; PubMed Central PMCID: PMC4179973.