ZLD10A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561384

CAS#: 1782064-91-8

Description: ZLD10A is a highly potent and selective small molecule inhibitor of EZH2. EZH2 overexpression is implicated in tumorigenesis and has been a candidate oncogene in several tumor types.


Price and Availability

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ZLD10A is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561384
Name: ZLD10A
CAS#: 1782064-91-8
Chemical Formula: C37H48N4O4
Exact Mass: 612.3676
Molecular Weight: 612.82
Elemental Analysis: C, 72.52; H, 7.90; N, 9.14; O, 10.44


Synonym: ZLD10A; ZLD-10-A; ZLD 10 A;

IUPAC/Chemical Name: 5-[Ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-4-methyl-4'-(4-morpholinylmethyl)[1,1'-biphenyl]-3-carboxamide

InChi Key: XZGRXFCVHBOVSL-UHFFFAOYSA-N

InChi Code: InChI=1S/C37H48N4O4/c1-4-41(30-13-17-44-18-14-30)35-22-29(28-11-9-27(10-12-28)24-40-15-19-45-20-16-40)21-33(25(35)2)36(42)38-23-34-32-8-6-5-7-31(32)26(3)39-37(34)43/h9-12,21-22,30H,4-8,13-20,23-24H2,1-3H3,(H,38,42)(H,39,43)

SMILES Code: O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C6CCCCC6=C(C)NC5=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Song X, Zhang L, Gao T, Ye T, Zhu Y, Lei Q, Feng Q, He B, Deng H, Yu L. Selective inhibition of EZH2 by ZLD10A blocks H3K27 methylation and kills mutant lymphoma cells proliferation. Biomed Pharmacother. 2016 Jul;81:288-94. doi: 10.1016/j.biopha.2016.04.019. Epub 2016 Apr 25. PubMed PMID: 27261606.