SAGE-217

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571265

CAS#: NONE

Description: SAGE 217 is discontinued now


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SAGE 217 is discontinued now


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571265
Name: SAGE-217
CAS#: NONE
Chemical Formula: C25H35N3O2
Exact Mass: 409.2729
Molecular Weight: 409.57
Elemental Analysis: C, 73.31; H, 8.61; N, 10.26; O, 7.81


Synonym: SAGE-217; SAGE 217; SAGE217

IUPAC/Chemical Name: 1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile

InChi Key: HARRKNSQXBRBGZ-GVKWWOCJSA-N

InChi Code: InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1

SMILES Code: O=C(CN1N=CC(C#N)=C1)[C@H]2CC[C@@]3([H])[C@]4([H])CC[C@]5([H])C[C@](C)(O)CC[C@]5([H])[C@@]4([H])CC[C@@]32C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Neuroactive steroids (NASs) have been shown to impact central nervous system (CNS) function through positive allosteric modulation of the GABA(A) receptor (GABA(A)-R).


References

1: Martinez Botella G, Salituro FG, Harrison BL, Beresis RT, Bai Z, Blanco MJ, Belfort GM, Dai J, Loya CM, Ackley MA, Althaus AL, Grossman SJ, Hoffmann E, Doherty JJ, Robichaud AJ. Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4 cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ Aminobutyric Acid)(A) Receptor. J Med Chem. 2017 Aug 17. doi: 10.1021/acs.jmedchem.7b00846. [Epub ahead of print] PubMed PMID: 28753313.