A-49816 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571252

CAS#: 78235-46-8

Description: A-49816 hydrochloride is a diuretic.


Price and Availability

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A 49816 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571252
Name: A-49816 hydrochloride
CAS#: 78235-46-8
Chemical Formula: C18H18Cl3NO5
Exact Mass: 433.0251
Molecular Weight: 434.69
Elemental Analysis: C, 49.74; H, 4.17; Cl, 24.47; N, 3.22; O, 18.40


Synonym: A-49816 hydrochloride; A49816 hydrochloride; A 49816 hydrochloride; A-49816 HCl

IUPAC/Chemical Name: Acetic acid, (4-(3-(aminomethyl)-4-hydroxybenzoyl)-2,3-dichlorophenoxy)-, ethyl ester, hydrochloride

InChi Key: WYFYYAHANZQLGG-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17Cl2NO5.ClH/c1-2-25-15(23)9-26-14-6-4-12(16(19)17(14)20)18(24)10-3-5-13(22)11(7-10)8-21;/h3-7,22H,2,8-9,21H2,1H3;1H

SMILES Code: O=C(OCC)COC1=CC=C(C(C2=CC=C(O)C(CN)=C2)=O)C(Cl)=C1Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Luther RR, Ringham GL, Steinberg FJ, Patterson KJ, Jordan DC, Rollins DE, Tolman KG. Pharmacologic effects of A-49816, a new high-ceiling diuretic. J Clin Pharmacol. 1987 Oct;27(10):794-801. PubMed PMID: 3323256.

2: Tolman KG, Gray PD, el Masry S, Luther RR, Janicki RS. Toxicity of uricosuric diuretics in rat hepatocyte culture. Biochem Pharmacol. 1989 Apr 1;38(7):1181-4. PubMed PMID: 2706015.