Acetaminophen
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571236

CAS#: 103-90-2

Description: Acetaminophen is an analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.


Price and Availability

Size
Price

100g
USD 150
Size
Price

500g
USD 250
Size
Price

1kg
USD 350

Acetaminophen, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571236
Name: Acetaminophen
CAS#: 103-90-2
Chemical Formula: C8H9NO2
Exact Mass: 151.0633
Molecular Weight: 151.17
Elemental Analysis: C, 63.56; H, 6.00; N, 9.27; O, 21.17


Synonym: Acetaminophen; Tylenol; 4-Acetamidophenol; APAP; 4'-Hydroxyacetanilide; NSC 3991; NSC 109028; Paracetamol.

IUPAC/Chemical Name: Acetamide, N-(4-hydroxyphenyl)-

InChi Key: RZVAJINKPMORJF-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

SMILES Code: CC(NC1=CC=C(O)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Aminoshariae A, Khan A. Acetaminophen: old drug, new issues. J Endod. 2015 May;41(5):588-93. doi: 10.1016/j.joen.2015.01.024. Epub 2015 Feb 27. Review. PubMed PMID: 25732401.

2: Shastri N. Intravenous acetaminophen use in pediatrics. Pediatr Emerg Care. 2015 Jun;31(6):444-8; quiz 449-50. doi: 10.1097/PEC.0000000000000463. Review. PubMed PMID: 26035501.

3: Brune K, Renner B, Tiegs G. Acetaminophen/paracetamol: A history of errors, failures and false decisions. Eur J Pain. 2015 Aug;19(7):953-65. doi: 10.1002/ejp.621. Epub 2014 Nov 27. Review. PubMed PMID: 25429980.

4: Parashar A. Pharmacological screening of glycine amino acid prodrug of acetaminophen. Indian J Pharmacol. 2015 Mar-Apr;47(2):202-5. doi: 10.4103/0253-7613.153431. PubMed PMID: 25878383; PubMed Central PMCID: PMC4386132.

5: Zhao Y, Harmatz JS, Epstein CR, Nakagawa Y, Kurosaki C, Nakamura T, Kadota T, Giesing D, Court MH, Greenblatt DJ. Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen. Br J Clin Pharmacol. 2015 Nov;80(5):1076-85. doi: 10.1111/bcp.12644. Epub 2015 Jun 8. PubMed PMID: 25808818; PubMed Central PMCID: PMC4631180.

6: Miettinen TP, Björklund M. NQO2 is a reactive oxygen species generating off-target for acetaminophen. Mol Pharm. 2014 Dec 1;11(12):4395-404. doi: 10.1021/mp5004866. Epub 2014 Oct 24. PubMed PMID: 25313982; PubMed Central PMCID: PMC4255684.

7: Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman RB, Klein TE. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26. doi: 10.1097/FPC.0000000000000150. PubMed PMID: 26049587; PubMed Central PMCID: PMC4498995.

8: Temple AR, Temple BR, Kuffner EK. Dosing and antipyretic efficacy of oral acetaminophen in children. Clin Ther. 2013 Sep;35(9):1361-75.e1-45. doi: 10.1016/j.clinthera.2013.06.022. Epub 2013 Aug 23. Review. PubMed PMID: 23972576.

9: Vokoun ES. Rationale for Use of Intravenous Acetaminophen in Special Operations Medicine. J Spec Oper Med. 2015 Summer;15(2):71-3. PubMed PMID: 26125167.

10: Jones J, Kahl S, Carvalho F, Barosa C, Roden M. Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water. Anal Biochem. 2015 Jun 15;479:37-9. doi: 10.1016/j.ab.2015.03.018. Epub 2015 Mar 20. PubMed PMID: 25800563.

11: Hayward KL, Powell EE, Irvine KM, Martin JH. Can paracetamol (acetaminophen) be administered to patients with liver impairment? Br J Clin Pharmacol. 2016 Feb;81(2):210-22. doi: 10.1111/bcp.12802. Epub 2015 Dec 25. Review. PubMed PMID: 26460177; PubMed Central PMCID: PMC4833155.

12: Curry SC, Padilla-Jones A, O'Connor AD, Ruha AM, Bikin DS, Wilkins DG, Rollins DE, Slawson MH, Gerkin RD; Acetaminophen Adduct Study Group. Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose. J Med Toxicol. 2015 Jun;11(2):169-78. doi: 10.1007/s13181-014-0431-2. PubMed PMID: 25288219; PubMed Central PMCID: PMC4469721.

13: Xu R, Wang Q, Zhang J, Zang M, Liu X, Yang J. Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat. Xenobiotica. 2014 Jun;44(6):541-6. doi: 10.3109/00498254.2013.858849. Epub 2013 Nov 19. PubMed PMID: 24251357.

14: Winnicka R, Kołaciński Z, Brzeznicki S, Wesołowski W, Kucharska M, Krakowiak A. [Intoxication or false-positive acetaminophen result of toxicological determinations? Two case reports]. Przegl Lek. 2013;70(8):695-7. Polish. PubMed PMID: 24466725.

15: Gollamudi J, Marks S. Oral versus Intravenous Acetaminophen #302. J Palliat Med. 2016 Feb;19(2):231-2. doi: 10.1089/jpm.2015.0501. PubMed PMID: 26840859.

16: Jóźwiak-Bebenista M, Nowak JZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014 Jan-Feb;71(1):11-23. Review. PubMed PMID: 24779190.

17: Ensafi AA, Ahmadi N, Rezaei B, Abarghoui MM. A new electrochemical sensor for the simultaneous determination of acetaminophen and codeine based on porous silicon/palladium nanostructure. Talanta. 2015 Mar;134:745-53. doi: 10.1016/j.talanta.2014.12.028. Epub 2014 Dec 30. PubMed PMID: 25618731.

18: Yu H, Barrass N, Gales S, Lenz E, Parry T, Powell H, Thurman D, Hutchison M, Wilson ID, Bi L, Qiao J, Qin Q, Ren J. Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey. Xenobiotica. 2015 Mar;45(3):270-7. doi: 10.3109/00498254.2014.973000. Epub 2014 Oct 22. PubMed PMID: 25335570.

19: Heard K, Green JL, Anderson V, Bucher-Bartelson B, Dart RC. Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing. Br J Clin Pharmacol. 2016 Mar;81(3):562-8. doi: 10.1111/bcp.12831. Epub 2016 Jan 14. PubMed PMID: 26584404; PubMed Central PMCID: PMC4767203.

20: KuKanich B. Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs. J Vet Pharmacol Ther. 2016 Oct;39(5):514-7. doi: 10.1111/jvp.12299. Epub 2016 Feb 20. PubMed PMID: 26896302.