beta-Aminoethylisothiuronium Bromide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571234

CAS#: 56-10-0

Description: beta-Aminoethylisothiuronium Bromide is a radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.


Price and Availability

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beta-Aminoethylisothiuronium Bromideis not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571234
Name: beta-Aminoethylisothiuronium Bromide
CAS#: 56-10-0
Chemical Formula: C3H11Br2N3S
Exact Mass: 278.904
Molecular Weight: 281.01
Elemental Analysis: C, 12.82; H, 3.95; Br, 56.87; N, 14.95; S, 11.41


Synonym: beta-Aminoethylisothiuronium Bromide

IUPAC/Chemical Name: Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide

InChi Key: XDVMCVGTDUKDHL-UHFFFAOYSA-N

InChi Code: InChI=1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H

SMILES Code: NC(SCCN)=N.[H]Br.[H]Br


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gabrilovich IM, Seleznev AF. [Protective effect of S-beta-aminoethylisothiuronium bromide on the T2 phage]. Radiobiologiia. 1965;5(2):314-5. Russian. PubMed PMID: 5871975.

2: BENSON RE, MICHAELSON SM, DOWNS WL, MAYNARD EA, SCOTT JK, HODGE HC, HOWLAND JW. Toxicological and radioprotection studies on S,beta-aminoethylisothiuronium bromide (AET). Radiat Res. 1961 Nov;15:561-72. PubMed PMID: 13867361.

3: Glembotskii YL, Grozdova TY. Experiments on the antimutagenic effect of AET (beta-aminoethylisothiuronium bromide) in Drosophila melanogaster. Sov Genet. 1973 Aug;7(2):213-20. PubMed PMID: 4216077.

4: BYCHKOVSKAIA IB, NOVOSELOVA GS. [ON THE EVALUATION OF THE RADIOPROTECTIVE ACTION OF BETA-AMINOETHYLISOTHIURONIUM (AET)]. Radiobiologiia. 1964;4:234-8. Russian. PubMed PMID: 14152986.

5: Naqvi S, Kumar KS, Venkitasubramanian TA. Effect of beta-aminoethylisothiuronium-bromide-hydrobromide on the acetate-1-14C incorporation into tissue lipids of irradiated rats. Experientia. 1968 Sep 15;24(9):891-2. PubMed PMID: 5709022.

6: Basu SK, Srinivasan MN, Chuttani K, George S. Radioprotection of spleen by a combination of 5-hydroxy-L-tryptophan and 2-aminoethylisothiuronium bromide hydrobromide in lethally irradiated rats. Strahlenther Onkol. 1992 Jul;168(7):427-31. PubMed PMID: 1496455.

7: PISAREVSKII AN, SELEZNEV AF. [ON A POSSIBLE MECHANISM OF PROTECTIVE PROPERTIES OF S-BETS-AMINOETHYLISOTHIURONIUM BROMIDE]. Biofizika. 1965;10:179-81. Russian. PubMed PMID: 14332035.

8: KERKIS IuIa, NAUMENKO IuN. [RADIOPROTECTIVE ACTION OF BETA-AMINOETHYLISOTHIURONIUM BR.HBR (AET) ON THE HEREDITARY STRUCTURES OF VARIOUS MAMMALIAN TISSUES]. Radiobiologiia. 1964;4:221-5. Russian. PubMed PMID: 14152984.

9: Kono A, Matsushima Y. Radiation-inactivation of aspartate amino transferase and its protection by 2-mercaptoethylamine and 2-aminoethylisothiuronium bromide. Chem Pharm Bull (Tokyo). 1977 Jan;25(1):147-50. PubMed PMID: 852080.

10: SMIRNOVA IB. [Effect of aminoethylisothiuronium bromide HBr on rakiation injuries of the mucous membrane of the small intestine]. Radiobiologiia. 1962;2:768-72. Russian. PubMed PMID: 13993093.

11: CONDIT PT, LEVY AH, SHNIDER BI, OVIEDO RG. Some effects of S,2-aminoethylisothiuronium bromide hydrobromide (AET) in man. Cancer. 1960 Jul-Aug;13:842-9. PubMed PMID: 13811473.

12: DISTEFANO V, LEARY DE, LITTLE KD. The pharmacological effects of some congeners of 2-aminoethylisothiuronium bromide (AET). J Pharmacol Exp Ther. 1959 Jun;126(2):158-63. PubMed PMID: 13665523.

13: Ozawa H, Kubota K, Hara Y. [Pharmacological action of 2-aminoethylisothiuronium (AET) derivatives. VI. Pharmacological action of 2-aminoethyl-1-p-chlorophenyl-isothiuronium bromide (AEPCIT)]. Yakugaku Zasshi. 1968 Oct;88(10):1352-5. Japanese. PubMed PMID: 5751317.

14: DISTEFANO V, KORN PS, LEARY DE. A comparison of the pharmacological effects of some compounds related to 2-aminoethylisothiuronium bromide hydrobromide (AET). Radiat Res. 1963 Feb;18:177-85. PubMed PMID: 14028067.

15: SHAPIRO B. The metabolism of the radiation protective agent 2-aminoethylisothiuronium bromide hydrobromide in mice and its alteration by radiation. Tech Doc Rep SAMTDR USAF Sch Aerosp Med. 1959 Dec;59:30:1-12. PubMed PMID: 13856347.

16: Phan Van Duyet, Nejtek VM, Dienstbier Z. [The effect of 2-aminoethylisothiuronium bromide-hydrobromide on 22Na transport in the isolated small intestine of normal and irradiated rats]. Strahlentherapie. 1967 Mar;132(3):448-53. German. PubMed PMID: 5588050.

17: Basu SK, Srinivasan MN, Chuttani K, George S. Protection to glycolysis by a combination of 5-hydroxy-L-tryptophan and 2-aminoethylisothiuronium bromide hydrobromide in lethally irradiated rats. Indian J Exp Biol. 1992 Sep;30(9):785-7. PubMed PMID: 1478714.

18: Filimonova MV, Proskuriakov SIa, Shevchenko LI, Shevchuk AS, Lushnikova GA, Makarchuk VM, Arzamastsev EV, Laba VI, Malinovskaia KI, Levitskaia EL. [Radioprotective properties of isothiourea derivatives with NO-inhibitory mechanism of action]. Radiats Biol Radioecol. 2012 Nov-Dec;52(6):593-601. Russian. PubMed PMID: 23516890.

19: Ozawa H, Hara Y. [Pharmacological actions of 2-aminoethylisothiuronium (AET) derivatives. V. Tachyphylaxis to 2-(2-diethylaminoethyl)-1-phenylisothiuronium bromide hydobromide (DEPT)]. Yakugaku Zasshi. 1968 Oct;88(10):1270-6. PubMed PMID: 5751302.

20: Davydov BI. [Quantitative evaluation (according to the toxic effect) of the absorption and elimination of cystaphos, S,beta-aminoethylisothiuronium and 5-methoxytryptamine with intraperitoneal and intragastric injections]. Radiobiologiia. 1972 Jan-Feb;12(1):136-40. Russian. PubMed PMID: 5040081.