A 81988

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571215

CAS#: 141887-34-5

Description: A 81988 is a selective angiotensin II antagonist for type I receptors. It is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.


Chemical Structure

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A 81988
CAS# 141887-34-5

Theoretical Analysis

MedKoo Cat#: 571215
Name: A 81988
CAS#: 141887-34-5
Chemical Formula: C23H22N6O2
Exact Mass: 414.18
Molecular Weight: 414.470
Elemental Analysis: C, 66.65; H, 5.35; N, 20.28; O, 7.72

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: A 81988; A-81988; A81988; Abbott 81988; Abbott-81988

IUPAC/Chemical Name: 3-Pyridinecarboxylic acid, 2-(propyl((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)amino)-

InChi Key: DLMNZGAILMQDHA-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H22N6O2/c1-2-14-29(22-20(23(30)31)8-5-13-24-22)15-16-9-11-17(12-10-16)18-6-3-4-7-19(18)21-25-27-28-26-21/h3-13H,2,14-15H2,1H3,(H,30,31)(H,25,26,27,28)

SMILES Code: O=C(C1=CC=CN=C1N(CCC)CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 414.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lee JY, Warner RB, Brune ME, Adler AL, Winn M, De B, Zydowsky TM, Opgenorth TJ, Kerkman DJ, DeBernardis JF. Cardiovascular effects of orally administered ABBOTT-81988, an angiotensin II antagonist, in conscious spontaneously hypertensive rats. Am J Hypertens. 1994 Nov;7(11):975-83. PubMed PMID: 7848624.

2: Hancock AA, Surber BW, Rotert G, Thomas S, Tasker AS, Sorensen BK, Vodenlich AD, Opgenorth TJ, Kerkman DJ, DeBernardis JF. [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267(1):49-54. PubMed PMID: 8206129.

3: Pollock DM, Polakowski JS, Divish BJ, Opgenorth TJ. Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition. Hypertension. 1993 May;21(5):660-6. PubMed PMID: 7684026.

4: Hancock AA, Buckner SA, Lee JY, Brune M, Morse PA, Oheim K, Warner RB, Winn M, Zydowsky TM, De B, et al. Receptor interactions of Abbott-81988, a highly potent, non-peptide angiotensin-II antagonist selective for type-1 receptors. J Recept Res. 1994 May;14(3-4):229-49. PubMed PMID: 8083867.

5: Lee JY, Buckner SA, Brune ME, Warner RB, Winn M, De B, Zydowsky TM, Opgenorth TJ, Kerkman DJ, Debernardis JF. Characterization of antihypertensive activity of ABBOTT-81988, a nonpeptide angiotensin II antagonist in the renal hypertensive rat. J Pharmacol Exp Ther. 1994 Jan;268(1):427-33. PubMed PMID: 8301584.

6: Solhaug MJ, Wallace MR, Granger JP. Nitric oxide and angiotensin II regulation of renal hemodynamics in the developing piglet. Pediatr Res. 1996 Mar;39(3):527-33. PubMed PMID: 8929876.

7: Madeddu P, Anania V, Varoni MV, Parpaglia PP, Demontis MP, Fattaccio MC, Palomba D, Pollock D, Glorioso N. Prevention by blockade of angiotensin subtype1-receptors of the development of genetic hypertension but not its heritability. Br J Pharmacol. 1995 Jun;115(4):557-62. PubMed PMID: 7582472; PubMed Central PMCID: PMC1908501.

8: Madeddu P, Salis MB, Emanueli C. Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice. Immunopharmacology. 1999 Dec;45(1-3):21-7. PubMed PMID: 10614985.

9: Winn M, De B, Zydowsky TM, Altenbach RJ, Basha FZ, Boyd SA, Brune ME, Buckner SA, Crowell D, Drizin I, et al. 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. J Med Chem. 1993 Sep 3;36(18):2676-88. PubMed PMID: 8410980.

10: Madeddu P, Emanueli C, Maestri R, Salis MB, Minasi A, Capogrossi MC, Olivetti G. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice. Hypertension. 2000 Jan;35(1 Pt 2):391-6. PubMed PMID: 10642330.

11: Madeddu P, Varoni MV, Palomba D, Emanueli C, Demontis MP, Glorioso N, Dessì-Fulgheri P, Sarzani R, Anania V. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation. 1997 Nov 18;96(10):3570-8. PubMed PMID: 9396457.

12: Madeddu P, Glorioso N. Does blockade of the renin-angiotensin system prevent heritability of genetic hypertension? Hypertension. 1995 Aug;26(2):9375. PubMed PMID: 7635550.

13: Pollock DM, Divish BJ, Polakowski JS, Opgenorth TJ. Angiotensin II receptor blockade improves renal function in rats with reduced renal mass. J Pharmacol Exp Ther. 1993 Nov;267(2):657-63. PubMed PMID: 8246138.