A 81282

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571214

CAS#: 141872-46-0

Description: A 81282 is a non-peptide selective antagonist of angiotensin receptors. A-81282 lowers blood pressure and has the potential to be a useful antihypertensive agent.


Price and Availability

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A 81282 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571214
Name: A 81282
CAS#: 141872-46-0
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:


Synonym: A 81282; A-81282; A81282; Abbott-81282; Abbott 81282

IUPAC/Chemical Name: 5-Pyrimidinecarboxylic acid, 4-(butyl((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)amino)-

InChi Key: AHZXSVWCNDLJER-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H23N7O2/c1-2-3-12-30(22-20(23(31)32)13-24-15-25-22)14-16-8-10-17(11-9-16)18-6-4-5-7-19(18)21-26-28-29-27-21/h4-11,13,15H,2-3,12,14H2,1H3,(H,31,32)(H,26,27,28,29)

SMILES Code: O=C(C1=CN=CN=C1N(CCCC)CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hancock AA, Buckner SA, Lee JY, Brune M, Morse PA, Oheim K, Warner RB, Winn M, Zydowsky TM, De B, et al. Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors. Life Sci. 1993;53(11):929-37. PubMed PMID: 8366760.

2: Lee JY, Brune ME, Warner RB, Buckner SB, Winn M, De B, Zydowsky TM, Opgenorth TJ, Kerkman DJ, DeBernardis JF. Antihypertensive activity of ABBOTT 81282, a nonpeptide angiotensin II antagonist, in the renal hypertensive rat. Pharmacology. 1993 Sep;47(3):176-87. PubMed PMID: 8415868.