A 80b

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571213

CAS#: 135561-94-3

Description: A-80b is a synthesized pyridazino[4,5-b]indole derivate. A 80b shows potent and long-lasting antihypertensive activity and lowers blood pressure. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. A-80b exerts a hypotensive and antihypertensive effect, possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.


Price and Availability

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A 80b is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571213
Name: A 80b
CAS#: 135561-94-3
Chemical Formula: C16H17N7
Exact Mass: 307.1545
Molecular Weight: 307.36
Elemental Analysis: C, 62.52; H, 5.58; N, 31.90


Synonym: A 80b; A-80b; A80b

IUPAC/Chemical Name: 1H-Pyridazino(4,5-b)indol-1-one, 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,5-dihydro-, methylhydrazone

InChi Key: LZAUTKZCXBBSMB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17N7/c1-9-8-10(2)23(22-9)16-14-13(15(19-17-3)20-21-16)11-6-4-5-7-12(11)18-14/h4-8,17-18H,1-3H3,(H,19,20)

SMILES Code: CC1=CC(C)=NN1C(C(N2)=C/3C4=C2C=CC=C4)=NNC3=N\NC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Frechilla D, Bernedo E, Castiella E, Lasheras B, Cenarruzabeitia E, Monge A, Aldana I, Alvarez T, Losa MJ, Font M. Antihypertensive and vasodilator effect of A-80b, a new pyridazino indole derivative. Eur J Pharmacol. 1992 Sep 4 ;219(3):409-14. PubMed PMID: 1425969.