T145

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561375

CAS#: 1021186-98-0

Description: T145 inhibits growth of Enterococcus faecalis, Staphylococcus aureus and Mycobacterium tuberculosis (Mtb) with sub μg/ml potencies that are potentially therapeutically valuable. T145 minimizes selection of spontaneous resistant mutants, a trait that prolongs longevity of a drug in clinical use.


Price and Availability

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T145 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561375
Name: T145
CAS#: 1021186-98-0
Chemical Formula: C18H16N2O5
Exact Mass: 340.1059
Molecular Weight: 340.34
Elemental Analysis: C, 63.53; H, 4.74; N, 8.23; O, 23.50


Synonym: T145, T-145, T 145

IUPAC/Chemical Name: (S)-N-(3-Dibenzo[1,4]dioxin-2-yl-2-oxo-oxazolidin-5-ylmethyl)-acetamide

InChi Key: CARSFZJMGZOXPN-ZDUSSCGKSA-N

InChi Code: InChI=1S/C18H16N2O5/c1-11(21)19-9-13-10-20(18(22)23-13)12-6-7-16-17(8-12)25-15-5-3-2-4-14(15)24-16/h2-8,13H,9-10H2,1H3,(H,19,21)/t13-/m0/s1

SMILES Code: CC(NC[C@H]1CN(C2=CC=C3OC4=CC=CC=C4OC3=C2)C(O1)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kaushik A, Heuer AM, Bell DT, Culhane JC, Ebner DC, Parrish N, Ippoliti JT, Lamichhane G. An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3572-6. doi: 10.1016/j.bmcl.2016.06.019. Epub 2016 Jun 9. PubMed PMID: 27329794; PubMed Central PMCID: PMC4955536.