A 85 4777

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571207

CAS#: 117009-82-2

Description: A 85 4777 is an antiinflammatory agent with nonclassical immunosuppressive properties. It is a homoperazine derivative.


Price and Availability

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Price

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Price

A 85 4777 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571207
Name: A 85 4777
CAS#: 117009-82-2
Chemical Formula: C20H32N2O2
Exact Mass: 332.2464
Molecular Weight: 332.49
Elemental Analysis: C, 72.25; H, 9.70; N, 8.43; O, 9.62


Synonym: A 85 4777; A 8547777; A85-4777

IUPAC/Chemical Name: 1H-1,4-Diazepine, 1-(3,5-bis(1,1-dimethylethyl)-4-hydroxybenzoyl)hexahydro-

InChi Key: LYRRSBJFMOFHBF-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H32N2O2/c1-19(2,3)15-12-14(13-16(17(15)23)20(4,5)6)18(24)22-10-7-8-21-9-11-22/h12-13,21,23H,7-11H2,1-6H3

SMILES Code: O=C(N1CCNCCC1)C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bartlett RR, Schleyerbach R, Schorlemmer KU, Wolf E. Pharmacological profile of A85 4777, a novel antiinflammatory agent with nonclassical immunosuppressive properties. Transplant Proc. 1990 Aug;22(4):1666-70. PubMed PMID: 2389430.

2: Schorlemmer H, Bartlett RR, Wolf E, Seiler FR. Prolongation of allogeneic transplanted skin grafts by A85 4777, a new immunosuppressive homopiperazine derivative. Transplant Proc. 1990 Aug;22(4):1671-3. PubMed PMID: 2389431.

3: Eisenmann D, Knipp H, Laube H, Stegmann T. Prevention of cytomegalovirus disease in heart transplant recipients by prophylaxis with cytomegalovirus hyperimmune globulin plus oral acyclovir. Transplant Proc. 1990 Oct;22(5):2322-3. PubMed PMID: 2171169.