A 802715

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571203

CAS#: 107767-58-8

Description: A 802715 is an anti-tumor agent that causes dose-dependent protection against lipopolysaccharide induced lethal shock. It counteracts tumor necrosis factor alpha toxicity. It may regulate cell growth and damage response in human cancer tumor cells.


Price and Availability

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A 802715 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571203
Name: A 802715
CAS#: 107767-58-8
Chemical Formula: C16H26N4O3
Exact Mass: 322.2005
Molecular Weight: 322.41
Elemental Analysis: C, 59.61; H, 8.13; N, 17.38; O, 14.89


Synonym: A 802715; A-802715; A802715

IUPAC/Chemical Name: 1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-7-propyl-

InChi Key: SBKAARSDXHSHSM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H26N4O3/c1-5-9-19-11-17-13-12(19)14(21)20(15(22)18(13)4)10-7-6-8-16(2,3)23/h11,23H,5-10H2,1-4H3

SMILES Code: O=C(N1CCCCC(C)(O)C)N(C)C2=C(N(CCC)C=N2)C1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bohm L, Theron T, Binder A. Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):1-10. PubMed PMID: 11118634.

2: Niehörster M, Schönharting M, Wendel A. A novel xanthine derivative counteracting in vivo tumor necrosis factor alpha toxicity in mice. Circ Shock. 1992 Aug;37(4):270-3. PubMed PMID: 1446384.

3: Hoffmann H, Weis M, Frank G, Birg A, Schönharting MM, Jochum M. Amelioration of endotoxin-induced acute lung injury in pigs by HWA 138 and A 80 2715: new analogs of pentoxifylline. Shock. 1995 Sep;4(3):166-70. PubMed PMID: 8574750.

4: Leist M, Auer-Barth S, Wendel A. Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines. J Pharmacol Exp Ther. 1996 Mar;276(3):968-76. PubMed PMID: 8786577.

5: Entzian P, Bitter-Suermann S, Burdon D, Ernst M, Schlaak M, Zabel P. Differences in the anti-inflammatory effects of theophylline and pentoxifylline: important for the development of asthma therapy? Allergy. 1998 Aug;53(8):749-54. PubMed PMID: 9722223.

6: Semmler J, Gebert U, Eisenhut T, Moeller J, Schönharting MM, Alléra A, Endres S. Xanthine derivatives: comparison between suppression of tumour necrosis factor-alpha production and inhibition of cAMP phosphodiesterase activity. Immunology. 1993 Apr;78(4):520-5. PubMed PMID: 8388363; PubMed Central PMCID: PMC1421886.

7: Lin Y, Goebels J, Rutgeerts O, Kasran A, Van Gool S, Ceuppens J, Schönharting M, Waer M. Use of the methylxanthine derivative A802715 in transplantation immunology: I. Strong in vitro inhibitory effects on CD28-costimulated T cell activities. Transplantation. 1997 Jun 27;63(12):1813-8. PubMed PMID: 9210510.

8: Rieneck K, Diamant M, Haahr PM, Schönharting M, Bendtzen K. In vitro immunomodulatory effects of pentoxifylline. Immunol Lett. 1993 Aug;37(2-3):131-8. PubMed PMID: 7505000.

9: Lin Y, Segers C, Mikhalsky D, Schönharting M, Waer M. Xanthines: ideal immunosuppressants for combination with cyclosporine? Transplant Proc. 1996 Dec;28(6):3102. PubMed PMID: 8962202.

10: Lin Y, Segers C, Mikhalsky D, Tjandra-Maga TB, Schönharting M, Waer M. Use of the methylxanthine derivative A802715 in transplantation immunology: II. In vivo experiments. Transplantation. 1997 Jun 27;63(12):1734-8. PubMed PMID: 9210496.

11: Lin Y, Schönharting M, Goebels J, Rutgeerts O, Mikhalsky D, Waer M. Use of methylxanthines (MeXa) as immunosuppressive drugs for organ transplantation. Transplant Proc. 1997 Feb-Mar;29(1-2):1279. PubMed PMID: 9123305.