A 74932

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571195

CAS#: 148201-60-9

Description: A 74932 is an inhibitor of DNA topoisomerases. It is a quinolone antibacterial agentand inhibitor of topoisomerase II enzyme. A-74932 possesses good activity in vivo against both systemic tumour and subcutaneously implanted murine solid tumours as well as human tumour xenografts.


Price and Availability

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A 74932 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571195
Name: A 74932
CAS#: 148201-60-9
Chemical Formula: C25H26ClFN4O5
Exact Mass: 516.1576
Molecular Weight: 516.95
Elemental Analysis: C, 58.09; H, 5.07; Cl, 6.86; F, 3.68; N, 10.84; O, 15.47


Synonym: A 74932; A-74932; A74932

IUPAC/Chemical Name: 6-((S)-2-((R)-2-aminopentanamido)pyrrolidin-1-yl)-5-fluoro-3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylic acid hydrochloride

InChi Key: UFBYBJURMXBKFU-VWJDFLIZSA-N

InChi Code: InChI=1S/C25H25FN4O5.ClH/c1-2-6-16(27)24(32)28-19-9-5-10-29(19)21-15(26)11-13-20-23(21)35-18-8-4-3-7-17(18)30(20)12-14(22(13)31)25(33)34;/h3-4,7-8,11-12,16,19H,2,5-6,9-10,27H2,1H3,(H,28,32)(H,33,34);1H/t16-,19+;/m1./s1

SMILES Code: O=C(C1=CN2C3=C(C(N4[C@H](NC([C@H](N)CCC)=O)CCC4)=C(F)C=C3C1=O)OC5=CC=CC=C25)O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Chu DT, Hallas R, Clement JJ, Alder J, McDonald E, Plattner JJ. Synthesis and antitumour activities of quinolone antineoplastic agents. Drugs Exp Clin Res. 1992;18(7):275-82. PubMed PMID: 1338309.

2: Snyder RD. Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ Mol Mutagen. 2000;35(1):13-21. PubMed PMID: 10692223.

3: Chu DT, Hallas R, Tanaka SK, Alder J, Balli D, Plattner JJ. Synthesis and antitumour activities of tetracyclic quinolone antineoplastic agents. Drugs Exp Clin Res. 1994;20(5):177-83. PubMed PMID: 7875053.

4: Permana PA, Snapka RM, Shen LL, Chu DT, Clement JJ, Plattner JJ. Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors. Biochemistry. 1994 Sep 20;33(37):11333-9. PubMed PMID: 7727384.