A 75998

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571187

CAS#: 135215-95-1

Description: A 75998 is an inhibitor of leuteinizing hormone-releasing hormone. It is a synthetic antagonist of leuteinizing hormone releasing hormone with potential for treatment of hormone-sensitive cancers and endometriosis.


Price and Availability

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Price

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A 75998 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571187
Name: A 75998
CAS#: 135215-95-1
Chemical Formula: C82H110ClN15O15
Exact Mass: 1579.7994
Molecular Weight: 1581.32
Elemental Analysis: C, 62.28; H, 7.01; Cl, 2.24; N, 13.29; O, 15.18


Synonym: A 75998; A-75998; A75998

IUPAC/Chemical Name: N-Acetyl-D-2-naphthylalanyl-4-chlorophenylalanyl-3-pyridylalanyl-seryl-N-methyltyrosyl-N(epsilon)-nicotinyllysyl-leucyl-N(epsilon)-isopropyllysyl-prolyl-alaninamide acetate

InChi Key: CHTZXZAMVXTFNE-DVKQQPHFSA-N

InChi Code: InChI=1S/C80H106ClN15O13.C2H4O2/c1-48(2)39-67(80(109)96(62-31-27-57-18-10-11-19-58(57)42-62)52(7)71(100)59(45-86-49(3)4)28-34-66(89-53(8)98)79(108)95-38-16-22-69(95)76(105)88-50(5)72(101)90-61-20-15-37-85-46-61)92-75(104)65(21-12-13-35-83-43-56-17-14-36-84-44-56)91-77(106)70(41-55-25-32-63(99)33-26-55)94(9)78(107)68(47-97)93-73(102)51(6)87-74(103)64(82)40-54-23-29-60(81)30-24-54;1-2(3)4/h10-11,14-15,17-20,23-27,29-33,36-37,42,44,46,48-52,59,64-70,83,86,97,99H,12-13,16,21-22,28,34-35,38-41,43,45,47,82H2,1-9H3,(H,87,103)(H,88,105)(H,89,98)(H,90,101)(H,91,106)(H,92,104)(H,93,102);1H3,(H,3,4)/t50-,51-,52-,59?,64-,65-,66-,67-,68-,69-,70-;/m0./s1

SMILES Code: C[C@@H](C(NC1=CC=CN=C1)=O)NC([C@H]2N(C([C@H](CCC(C([C@H](C)N(C([C@H](CC(C)C)NC([C@H](CCCCNCC3=CN=CC=C3)NC([C@H](CC4=CC=C(O)C=C4)N(C([C@H](CO)NC([C@H](C)NC([C@H](CC5=CC=C(Cl)C=C5)N)=O)=O)=O)C)=O)=O)=O)C6=CC=C7C=CC=CC7=C6)=O)CNC(C)C)NC(C)=O)=O)CCC2)=O.CC(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Haviv F, Bush EN, Knittle J, Greer J. LHRH antagonists. Pharm Biotechnol. 1998;11:131-49. Review. PubMed PMID: 9760679.

2: Cannon JB, Krill SL, Porter WR. Physicochemical properties of A-75998, an antagonist of luteinizing hormone releasing hormone. J Pharm Sci. 1995 Aug;84(8):953-8. PubMed PMID: 7500280.

3: Haviv F, Fitzpatrick TD, Nichols CJ, Bush EN, Diaz G, Bammert G, Nguyen AT, Johnson ES, Knittle J, Greer J. In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem. 1994 Mar 4;37(5):701-5. PubMed PMID: 7510341.