BC12

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561362

CAS#: 423744-89-2

Description: BC12 is a potent inhibitor of IL-2 secretion. BC12 exhibits unusually potent immunosuppressive and immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production.


Price and Availability

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BC12 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561362
Name: BC12
CAS#: 423744-89-2
Chemical Formula: C21H19N3O3
Exact Mass: 361.1426
Molecular Weight: 361.4
Elemental Analysis: C, 69.79; H, 5.30; N, 11.63; O, 13.28


Synonym: BC12; BC-12; BC 12;

IUPAC/Chemical Name: 5-{3-[4-(Dimethylamino)phenyl]-2-propen-1-ylidene}-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione

InChi Key: WSBFTODMEZTVBC-ZOQHSEBNSA-N

InChi Code: InChI=1S/C21H19N3O3/c1-23(2)16-13-11-15(12-14-16)7-6-10-18-19(25)22-21(27)24(20(18)26)17-8-4-3-5-9-17/h3-14H,1-2H3,(H,22,25,27)/b7-6+,18-10+

SMILES Code: O=C1NC(/C(C(N1C2=CC=CC=C2)=O)=C\C=C\C3=CC=C(N(C)C)C=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Xu C, Wyman AR, Alaamery MA, Argueta SA, Ivey FD, Meyers JA, Lerner A, Burdo TH, Connolly T, Hoffman CS, Chiles TC. Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes. Int Immunopharmacol. 2016 Sep;38:223-32. doi: 10.1016/j.intimp.2016.06.004. Epub 2016 Jun 13. PubMed PMID: 27302770.