A 74704

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571178

CAS#: 129467-45-4

Description: A 74704 is a pseudo C2-symmetric inhibitor of HIV-1 protease and its diester analog.


Price and Availability

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A 74704 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571178
Name: A 74704
CAS#: 129467-45-4
Chemical Formula: C43H52N4O7
Exact Mass: 736.3836
Molecular Weight: 736.91
Elemental Analysis: C, 70.09; H, 7.11; N, 7.60; O, 15.20


Synonym: A 74704; A-74704; A74704

IUPAC/Chemical Name: L-Arabinitol, 1,2,4,5-tetradeoxy-2,4-bis((3-methyl-1-oxo-2-(((phenylmethoxy)carbonyl)amino)butyl)amino)-1,5-diphenyl-, (2(S),4(S))-

InChi Key: GEANBHANAKKWSL-KRNRTSONSA-N

InChi Code: InChI=1S/C43H52N4O7/c1-29(2)37(46-42(51)53-27-33-21-13-7-14-22-33)40(49)44-35(25-31-17-9-5-10-18-31)39(48)36(26-32-19-11-6-12-20-32)45-41(50)38(30(3)4)47-43(52)54-28-34-23-15-8-16-24-34/h5-24,29-30,35-39,48H,25-28H2,1-4H3,(H,44,49)(H,45,50)(H,46,51)(H,47,52)/t35-,36-,37?,38?,39?/m0/s1

SMILES Code: OC([C@@H](NC(C(NC(OCC1=CC=CC=C1)=O)C(C)C)=O)CC2=CC=CC=C2)[C@@H](NC(C(NC(OCC3=CC=CC=C3)=O)C(C)C)=O)CC4=CC=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Rao BG, Murcko MA. Free energy perturbation studies on binding of A-74704 and its diester analog to HIV-1 protease. Protein Eng. 1996 Sep;9(9):767-71. PubMed PMID: 8888142.