A71378

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571177

CAS#: 127902-33-4

Description: A71378 is a Cholecystokinin (CCK) receptor agonist with high potency & selectivity for CCK-A receptors.


Price and Availability

Size
Price

Size
Price

Size
Price

A71378 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 571177
Name: A71378
CAS#: 127902-33-4
Chemical Formula: C48H62N8O13S
Exact Mass: 990.4157
Molecular Weight: 991.13
Elemental Analysis: C, 58.17; H, 6.31; N, 11.31; O, 20.98; S, 3.23


Synonym: A71378; A-71378; A 71378

IUPAC/Chemical Name: L-Phenylalaninamide, N-(1-oxo-3-(4-(sulfooxy)phenyl)propyl)-L-norleucylglycyl-L-tryptophyl-L-norleucyl-N-methyl-L-alpha-aspartyl-

InChi Key: YJRSAZMDFOJHLB-HECCNADXSA-N

InChi Code: InChI=1S/C48H62N8O13S/c1-4-6-16-36(52-41(57)24-21-30-19-22-33(23-20-30)69-70(66,67)68)45(62)51-29-42(58)53-39(26-32-28-50-35-18-12-11-15-34(32)35)46(63)54-37(17-7-5-2)48(65)56(3)40(27-43(59)60)47(64)55-38(44(49)61)25-31-13-9-8-10-14-31/h8-15,18-20,22-23,28,36-40,50H,4-7,16-17,21,24-27,29H2,1-3H3,(H2,49,61)(H,51,62)(H,52,57)(H,53,58)(H,54,63)(H,55,64)(H,59,60)(H,66,67,68)/t36-,37-,38-,39-,40-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)N(C([C@H](CCCC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCCC)NC(CCC4=CC=C(OS(=O)(O)=O)C=C4)=O)=O)=O)=O)=O)C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Davidowa H, Wetzel K, Henklein P. Neostriatal neurons of rats can be influenced by cholecystokinin-A receptor agonists. Neuropeptides. 1997 Jun;31(3):231-5. PubMed PMID: 9243519.

2: Qian JM, Rowley WH, Jensen RT. Gastrin and CCK activate phospholipase C and stimulate pepsinogen release by interacting with two distinct receptors. Am J Physiol. 1993 Apr;264(4 Pt 1):G718-27. PubMed PMID: 8476056.

3: Davidowa H, Wetzel K, Vierig G. Effects of cholecystokinin agonists on striatal neurons are reduced by acetylcholine. Peptides. 1997;18(4):541-5. PubMed PMID: 9210173.

4: Giralt M, Vergara P. Inhibition by CCK of ascending contraction elicited by mucosal stimulation in the duodenum of the rat. Neurogastroenterol Motil. 2000 Apr;12(2):173-80. PubMed PMID: 10877605.

5: Lin CW, Bianchi BR, Miller TR, Witte DG, Wolfram CA. Both CCK-A and CCK-B/gastrin receptors mediate pepsinogen release in guinea pig gastric glands. Am J Physiol. 1992 Jun;262(6 Pt 1):G1113-20. PubMed PMID: 1616041.

6: Lodge DJ, Lawrence AJ. Comparative analysis of the central CCK system in Fawn Hooded and Wistar Kyoto rats: extended localisation of CCK-A receptors throughout the rat brain using a novel radioligand. Regul Pept. 2001 Jun 15;99(2-3):191-201. PubMed PMID: 11384782.

7: Heidel E, Davidowa H. Interactive effects of cholecystokinin-8S and serotonin on spontaneously active neurons in ventromedial hypothalamic slices. Neuropeptides. 1998 Oct;32(5):423-9. PubMed PMID: 9845002.

8: Pradhan TK, Qian JM, Sutliff VE, Mantey SA, Jensen RT. Identification of CCK-A receptors on chief cells with use of a novel, highly selective ligand. Am J Physiol. 1995 Apr;268(4 Pt 1):G605-12. PubMed PMID: 7733286.

9: Tang LH, Miller MD, Goldenring JR, Modlin IM, Hersey SJ. Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion. Am J Physiol. 1993 Nov;265(5 Pt 1):G865-72. PubMed PMID: 8238515.

10: Rex A, Fink H. Effects of cholecystokinin-receptor agonists on cortical 5-HT release in guinea pigs on the X-maze. Peptides. 1998;19(3):519-26. PubMed PMID: 9533640.

11: Dabrowski A, Detjen KM, Logsdon CD, Williams JA. Stimulation of both CCK-A and CCK-B receptors activates MAP kinases in AR42J and receptor-transfected CHO cells. Digestion. 1997;58(4):361-7. PubMed PMID: 9324163.

12: Voits M, Voigt JP, Boomgaarden M, Henklein P, Fink H. Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S. Peptides. 1996;17(2):355-7. PubMed PMID: 8801546.

13: Parrott RF. Peripheral and central effects of CCK receptor agonists on operant feeding in pigs. Physiol Behav. 1993 Feb;53(2):367-72. PubMed PMID: 8446699.

14: Meyer G, Beinborn M, Sewing KF. Characterization of CCKA receptor mediated pepsinogen secretion in porcine chief cells. Pharmacology. 1996 Jul;53(1):48-59. PubMed PMID: 8875601.

15: Giralt M, Vergara P. Both afferent and efferent nerves are implicated in cholecytokinin motor actions in the small intestine of the rat. Regul Pept. 1999 May 31;81(1-3):73-80. PubMed PMID: 10395411.

16: Lin CW, Holladay MW, Witte DG, Miller TR, Wolfram CA, Bianchi BR, Bennett MJ, Nadzan AM. A71378: a CCK agonist with high potency and selectivity for CCK-A receptors. Am J Physiol. 1990 Apr;258(4 Pt 1):G648-51. PubMed PMID: 2333977.