A 65317

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571167

CAS#: 122224-84-4

Description: A 65317 is a selective renin inhibitor that causes a blockade of the renin-angiotensin system.


Chemical Structure

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A 65317
CAS# 122224-84-4

Theoretical Analysis

MedKoo Cat#: 571167
Name: A 65317
CAS#: 122224-84-4
Chemical Formula: C38H58N6O9
Exact Mass: 742.43
Molecular Weight: 742.920
Elemental Analysis: C, 61.44; H, 7.87; N, 11.31; O, 19.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: A 65317; A65317; A-65317

IUPAC/Chemical Name: 1H-Imidazole-4-propanamide, N-(1-(cyclohexylmethyl)-2-(3-ethyl-2-oxo-5-oxazolidinyl)-2-hydroxyethyl)-alpha-((5-methyl-1,4-dioxo-2-(phenylmethyl)-8,10,13-trioxa-5-azatetradec-1-yl)amino)-, (5S-(5R*(1R*(R*(S*)),2S*)))-

InChi Key: JZRFAIHFMIECQR-JAUPOCBBSA-N

InChi Code: InChI=1S/C38H58N6O9/c1-4-44-24-33(53-38(44)49)35(46)31(20-28-13-9-6-10-14-28)41-37(48)32(22-30-23-39-25-40-30)42-36(47)29(19-27-11-7-5-8-12-27)21-34(45)43(2)15-16-51-26-52-18-17-50-3/h5,7-8,11-12,23,25,28-29,31-33,35,46H,4,6,9-10,13-22,24,26H2,1-3H3,(H,39,40)(H,41,48)(H,42,47)/t29-,31+,32-,33+,35?/m1/s1

SMILES Code: O=C(N[C@@H](CC1CCCCC1)C([C@@H]2CN(CC)C(O2)=O)O)[C@H](NC([C@H](CC3=CC=CC=C3)CC(N(C)CCOCOCCOC)=O)=O)CC4=CNC=N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 742.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Verburg KM, Kadam JR, Young GA, Rosenberg SH, Kleinert HD. Effect of intrarenal renin inhibition on renal hemodynamics and excretory function. Am J Physiol. 1990 Jul;259(1 Pt 2):R7-14. PubMed PMID: 2197881.

2: Dayton BD, Stein HH, Cohen J, Baker WR, Boyd SA, Condon SL, Donner BG, Fung AK, Luly JR, Rosenberg SH, et al. Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors. Clin Chem. 1992 Nov;38(11):2239-43. PubMed PMID: 1330373.

3: Kim J, Hughbanks T. Synthesis and structures of new ternary aluminum chalcogenides: LiAlSe2, alpha-LiAlTe2, and beta-LiAlTe2. Inorg Chem. 2000 Jul 10;39(14):3092-7. PubMed PMID: 11196906.