Matrine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540281

CAS#: 519-02-8

Description: Matrine is found in Sophora. It displays many biological activities, including inducing apoptosis in hepatoma cells and non-small cell lung cancer cells, decreasing pain responses in opioid-dependent manner, regulating glutamate signaling, and decreasing seizures.


Price and Availability

Size
Price

100mg
USD 240
Size
Price

250mg
USD 440
Size
Price

500mg
USD 785

Matrine purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 540281
Name: Matrine
CAS#: 519-02-8
Chemical Formula: C15H24N2O
Exact Mass: 248.1889
Molecular Weight: 248.37
Elemental Analysis: C, 72.54; H, 9.74; N, 11.28; O, 6.44


Synonym: Matridin-15-one; Matrine; NSC 146051; NSC146051; NSC-146051;

IUPAC/Chemical Name: (41S,7aS,13aR,13bR)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one

InChi Key: ZSBXGIUJOOQZMP-JLNYLFASSA-N

InChi Code: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1

SMILES Code: O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@H]([C@@H]34)CN12


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Sun B, Xu M. Matrine inhibits the migratory and invasive properties of nasopharyngeal carcinoma cells. Mol Med Rep. 2015 Jun;11(6):4158-64. doi: 10.3892/mmr.2015.3276. Epub 2015 Jan 29. PubMed PMID: 25633440; PubMed Central PMCID: PMC4394955.

2: Wang Z, Wu Y, Wang Y, Jin Y, Ma X, Zhang Y, Ren H. Matrine inhibits the invasive properties of human glioma cells by regulating epithelial to mesenchymal transition. Mol Med Rep. 2015 May;11(5):3682-6. doi: 10.3892/mmr.2015.3167. Epub 2015 Jan 8. PubMed PMID: 25572156.

3: Liao H, Zhao X, Qu J, Zhang J, Cai H. Matrine suppresses invasion and metastasis of NCI-H1299 cells by enhancing microRNA-133a expression. Int J Clin Exp Med. 2015 Jul 15;8(7):10714-22. eCollection 2015. PubMed PMID: 26379863; PubMed Central PMCID: PMC4565246.

4: Xie SB, He XX, Yao SK. Matrine-induced autophagy regulated by p53 through AMP-activated protein kinase in human hepatoma cells. Int J Oncol. 2015 Aug;47(2):517-26. doi: 10.3892/ijo.2015.3023. Epub 2015 May 28. PubMed PMID: 26034977.

5: Luo T, Zou QX, He YQ, Wang HF, Li N, Zeng XH. Matrine inhibits mouse sperm function by reducing sperm [Ca2+]i and phospho-ERK1/2. Cell Physiol Biochem. 2015;35(1):374-85. doi: 10.1159/000369703. Epub 2015 Jan 13. PubMed PMID: 25591778.

6: Gong X, Gao Y, Guo G, Vondran FW, Schwartlander R, Efimova E, Pless G, Sauera IM, Neuhaus P. Effect of matrine on primary human hepatocytes in vitro. Cytotechnology. 2015 Mar;67(2):255-65. doi: 10.1007/s10616-013-9680-1. Epub 2014 Jan 21. PubMed PMID: 24445680; PubMed Central PMCID: PMC4329302.

7: Yang N, Han F, Cui H, Huang J, Wang T, Zhou Y, Zhou J. Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling. Pharmacol Rep. 2015 Apr;67(2):388-93. doi: 10.1016/j.pharep.2014.10.016. Epub 2014 Nov 5. PubMed PMID: 25712669.

8: Wang HQ, Jin JJ, Wang J. Matrine induces mitochondrial apoptosis in cisplatin-resistant non-small cell lung cancer cells via suppression of β-catenin/survivin signaling. Oncol Rep. 2015 May;33(5):2561-6. doi: 10.3892/or.2015.3844. Epub 2015 Mar 9. PubMed PMID: 25760455.

9: Zhao P, Zhou R, Zhu XY, Hao YJ, Li N, Wang J, Niu Y, Sun T, Li YX, Yu JQ. Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice. Int J Mol Med. 2015 Sep;36(3):633-44. doi: 10.3892/ijmm.2015.2260. Epub 2015 Jun 24. PubMed PMID: 26135032; PubMed Central PMCID: PMC4533779.

10: Zhou YH, Feng JY, You LS, Meng HT, Qian WB. Matrine and CYC116 synergistically inhibit growth and induce apoptosis in multiple myeloma cells. Chin J Integr Med. 2015 Aug;21(8):635-9. doi: 10.1007/s11655-015-1975-y. Epub 2015 Mar 24. PubMed PMID: 25804197.

11: Ma Y, Zou F, Xiong J, Wan W, Yin L, Li X, Bei Z, Yuan L, Meng S, Wang J, Song G. Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling. Cancer Cell Int. 2015 Jun 11;15:59. doi: 10.1186/s12935-015-0210-4. eCollection 2015. PubMed PMID: 26113801; PubMed Central PMCID: PMC4480578.

12: Ma L, Zhu Z, Sun X, Jiang L, Bai Y, Lu X, Zhou M, Qian S, Li J. [Growth inhibition effect of matrine on K562 cells mediated by IL-6/JAK/STAT3 signaling pathway]. Zhonghua Xue Ye Xue Za Zhi. 2015 May;36(5):422-6. doi: 10.3760/cma.j.issn.0253-2727.2015.05.015. Chinese. PubMed PMID: 26031532.

13: Xie BS, He XX, Ai ZL, Yao SK. Involvement of β-catenin in matrine-induced autophagy and apoptosis in WB-F344 cells. Mol Med Rep. 2014 Jun;9(6):2547-53. doi: 10.3892/mmr.2014.2107. Epub 2014 Apr 2. PubMed PMID: 24718323.

14: Zeng XY, Wang H, Bai F, Zhou X, Li SP, Ren LP, Sun RQ, Xue CC, Jiang HL, Hu LH, Ye JM. Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. Br J Pharmacol. 2015 Sep;172(17):4303-18. doi: 10.1111/bph.13209. Epub 2015 Jul 14. PubMed PMID: 26040411; PubMed Central PMCID: PMC4556469.

15: Zhang L, Zhang H, Zhu Z, Jiang L, Lu X, Zhou M, Sun X, He L, Bai Y, Ma L. Matrine regulates immune functions to inhibit the proliferation of leukemic cells. Int J Clin Exp Med. 2015 Apr 15;8(4):5591-600. eCollection 2015. PubMed PMID: 26131142; PubMed Central PMCID: PMC4484016.

16: Li Y, Zhang ZN, Zhao HM, Tong ZC, Yang J, Wang H, Liang XJ. Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway. Anticancer Drugs. 2014 Oct;25(9):1035-43. doi: 10.1097/CAD.0000000000000136. PubMed PMID: 24999836.

17: Shao J, Wang T, Yan Y, Shi G, Cheng H, Wu D, Wang C. Matrine reduces yeast-to-hypha transition and resistance of a fluconazole-resistant strain of Candida albicans. J Appl Microbiol. 2014 Sep;117(3):618-26. doi: 10.1111/jam.12555. Epub 2014 Jun 26. PubMed PMID: 24860982.

18: Lu S, Xiao X, Cheng M. Matrine inhibits IL-1β-induced expression of matrix metalloproteinases by suppressing the activation of MAPK and NF-κB in human chondrocytes in vitro. Int J Clin Exp Pathol. 2015 May 1;8(5):4764-72. eCollection 2015. PubMed PMID: 26191166; PubMed Central PMCID: PMC4503038.

19: Zhang S, Cheng B, Li H, Xu W, Zhai B, Pan S, Wang L, Liu M, Sun X. Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway. Mol Biol Rep. 2014;41(4):2101-8. doi: 10.1007/s11033-014-3059-z. Epub 2014 Jan 23. PubMed PMID: 24452711.

20: Rong B, Zhao C, Gao W, Yang S. Matrine promotes the efficacy and safety of platinum-based doublet chemotherapy for advanced non-small cell lung cancer. Int J Clin Exp Med. 2015 Sep 15;8(9):14701-17. eCollection 2015. PubMed PMID: 26628952; PubMed Central PMCID: PMC4658841.