A-57696

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571147

CAS#: 125598-87-0

Description: A-57696 is a cholecystokinin antagonist. It is selective for cortical CCK-B receptors (IC50 = 25 nM), compared with pancreatic CCK-A receptors (IC50 = 15 microM). It is a competitive antagonist in reversing CCK8-stimulated pancreatic amylase secretion and phosphoinositide breakdown. A-57696 behaved as a partial agonist in stimulating calcium mobilization at CCK-B/gastrin receptors.


Price and Availability

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A 57696 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571147
Name: A-57696
CAS#: 125598-87-0
Chemical Formula: C35H47N7O8
Exact Mass: 693.3486
Molecular Weight: 693.8
Elemental Analysis: C, 60.59; H, 6.83; N, 14.13; O, 18.45


Synonym: A 57696; A-57696; A57696

IUPAC/Chemical Name: L-Phenylalanine, N-(N-(N-(N-((1,1-dimethylethoxy)carbonyl)-L-tryptophyl)-L-leucyl)-L-alpha-aspartyl)-, 1-hydrazide

InChi Key: XUIILZAJJORFPN-JSRHHAARSA-N

InChi Code: InChI=1S/C35H47N7O8/c1-20(2)14-27(31(46)40-29(19-44)33(48)38-24(18-43)15-21-10-12-22(13-11-21)30(45)42-36)39-32(47)28(41-34(49)50-35(3,4)5)16-23-17-37-26-9-7-6-8-25(23)26/h6-13,17-18,20,24,27-29,37,44H,14-16,19,36H2,1-5H3,(H,38,48)(H,39,47)(H,40,46)(H,41,49)(H,42,45)/t24-,27-,28-,29-/m0/s1

SMILES Code: O=C(OC(C)(C)C)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC3=CC=C(C(NN)=O)C=C3)C=O)=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lin CW, Holladay MW, Barrett RW, Wolfram CA, Miller TR, Witte D, Kerwin JF Jr, Wagenaar F, Nadzan AM. Distinct requirements for activation at CCK-A and CCK-B/gastrin receptors: studies with a C-terminal hydrazide analogue of cholecystokinin tetrapeptide (30-33). Mol Pharmacol. 1989 Dec;36(6):881-6. PubMed PMID: 2601685.

2: Oliver AS, Vigna SR. CCK-X receptors in the endothermic mako shark (Isurus oxyrinchus). Gen Comp Endocrinol. 1996 Apr;102(1):61-73. PubMed PMID: 8860310.