A 49816

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571133

CAS#: 78235-72-0

Description: A 49816 is a high-ceiling diuretic.


Price and Availability

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Price

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A 49816 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571133
Name: A 49816
CAS#: 78235-72-0
Chemical Formula: C18H17Cl2NO5
Exact Mass: 397.0484
Molecular Weight: 398.24
Elemental Analysis: C, 54.29; H, 4.30; Cl, 17.80; N, 3.52; O, 20.09


Synonym: A 49816; A-49816; A49816

IUPAC/Chemical Name: Acetic acid, (4-(3-(aminomethyl)-4-hydroxybenzoyl)-2,3-dichlorophenoxy)-, ethyl ester

InChi Key: KWDSYQYCWWCCAV-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17Cl2NO5/c1-2-25-15(23)9-26-14-6-4-12(16(19)17(14)20)18(24)10-3-5-13(22)11(7-10)8-21/h3-7,22H,2,8-9,21H2,1H3

SMILES Code: O=C(OCC)COC1=CC=C(C(C2=CC=C(O)C(CN)=C2)=O)C(Cl)=C1Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Luther RR, Ringham GL, Steinberg FJ, Patterson KJ, Jordan DC, Rollins DE, Tolman KG. Pharmacologic effects of A-49816, a new high-ceiling diuretic. J Clin Pharmacol. 1987 Oct;27(10):794-801. PubMed PMID: 3323256.
2: Tolman KG, Gray PD, el Masry S, Luther RR, Janicki RS. Toxicity of uricosuric diuretics in rat hepatocyte culture. Biochem Pharmacol. 1989 Apr 1; 38(7):1181-4. PubMed PMID: 2706015.