A 30312

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571113

CAS#: 144092-65-9

Description: A 30312 is a biochemical that may specifically overcome multidrug resistance without the serious hypotensive effects associated with calcium antagonists. It is a fused indole that has been found to overcome multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vinblastine, and vincristine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells.


Price and Availability

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A 30312 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571113
Name: A 30312
CAS#: 144092-65-9
Chemical Formula: C19H21ClN2O
Exact Mass: 328.1342
Molecular Weight: 328.84
Elemental Analysis: C, 69.40; H, 6.44; Cl, 10.78; N, 8.52; O, 4.87


Synonym: A 30312; A30312; A-30312

IUPAC/Chemical Name: 1H-Pyrido(4,3-b)indole, 2,3,4,5-tetrahydro-8-methoxy-2-(phenylmethyl)-, monohydrochloride

InChi Key: KHANUNWSUNXEKV-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20N2O.ClH/c1-22-15-7-8-18-16(11-15)17-13-21(10-9-19(17)20-18)12-14-5-3-2-4-6-14;/h2-8,11,20H,9-10,12-13H2,1H3;1H

SMILES Code: COC1=CC2=C(NC3=C2CN(CC4=CC=CC=C4)CC3)C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kadam S, Maus M, Poddig J, Schmidt S, Rasmussen R, Novosad E, Plattner J, McAlpine J. Reversal of multidrug resistance by two novel indole derivatives. Cancer Res. 1992 Sep 1;52(17):4735-40. PubMed PMID: 1355008.