A 33853

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571108

CAS#: 80148-45-4

Description: A 33853 is an antibiotic isolated from culture broth of Streptomyces sp. It is a tetraacetyl with an anhydride moeity.


Price and Availability

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A 33853 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571108
Name: A 33853
CAS#: 80148-45-4
Chemical Formula: C20H13N3O6
Exact Mass: 391.0804
Molecular Weight: 391.34
Elemental Analysis: C, 61.38; H, 3.35; N, 10.74; O, 24.53


Synonym: A 33853; A33853; A-33853

IUPAC/Chemical Name: 4-Benzoxazolecarboxylic acid, 2-(3-hydroxy-2-(((3-hydroxy-2-pyridinyl)carbonyl)amino)phenyl)-

InChi Key: LJVDLJDWXVPUAB-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13N3O6/c24-12-6-1-4-10(15(12)22-18(26)17-13(25)7-3-9-21-17)19-23-16-11(20(27)28)5-2-8-14(16)29-19/h1-9,24-25H,(H,22,26)(H,27,28)

SMILES Code: O=C(C1=C2N=C(C3=CC=CC(O)=C3NC(C4=NC=CC=C4O)=O)OC2=CC=C1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Michel KH, Boeck LD, Hoehn MM, Jones ND, Chaney MO. The discovery, fermentation, isolation, and structure of antibiotic A33853 and its tetraacetyl
derivative. J Antibiot (Tokyo). 1984 May;37(5):441-5. PubMed PMID: 6547431.

2: Tipparaju SK, Joyasawal S, Pieroni M, Kaiser M, Brun R, Kozikowski AP. In
pursuit of natural product leads: synthesis and biological evaluation of 2-[3 hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and its analogues: discovery of N-(2-benzoxazol2-ylphenyl)benzamides as novel antileishmanial chemotypes. J Med Chem. 2008 Dec 11;51(23):7344-7. doi: 10.1021/jm801241n. PubMed PMID: 18989953.

3: Lv M, Zhao J, Deng Z, Yu Y. Characterization of the Biosynthetic Gene Cluster for Benzoxazole Antibiotics A33853 Reveals Unusual Assembly Logic. Chem Biol. 2015 Oct 22;22(10):1313-24. doi: 10.1016/j.chembiol.2015.09.005. PubMed PMID: 26496684.