A 31472

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571105

CAS#: 69319-52-4

Description: A 31472 is a tetracyclic spiro amine that has affinity for dopamine D-2 receptors. These compounds are important for defining the pharmacophore for D-2 antagonist activity due to their limited conformational freedom.


Price and Availability

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A 31472 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571105
Name: A 31472
CAS#: 69319-52-4
Chemical Formula: C22H22ClN
Exact Mass: 335.1441
Molecular Weight: 335.88
Elemental Analysis: C, 78.67; H, 6.60; Cl, 10.55; N, 4.17


Synonym: A 31472; A31472; A-31472

IUPAC/Chemical Name: Spiro(2-cyclohexene-1,5'-(5H)dibenzo(a,d)cyclohepten)-4-amine, 3'-chloro-N,N-dimethyl-, (1S,4R)-

InChi Key: FZXSXMYFIZKXPT-SIKLNZKXSA-N

InChi Code: InChI=1S/C22H22ClN/c1-24(2)19-11-13-22(14-12-19)20-6-4-3-5-16(20)7-8-17-9-10-18(23)15-21(17)22/h3-11,13,15,19H,12,14H2,1-2H3/t19-,22+/m0/s1

SMILES Code: CN(C)[C@H]1C=C[C@@]2(C3=CC(Cl)=CC=C3C=CC4=CC=CC=C42)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Froimowitz M, Rämsby S. Conformational properties of semirigid antipsychotic
drugs: the pharmacophore for dopamine D-2 antagonist activity. J Med Chem. 1991
May;34(5):1707-14. PubMed PMID: 1674541.