P-2281

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561298

CAS#: 1112994-35-0

Description: P-2281 is a mTOR inhibitor and is efficacious in a murine model of human colitis. In the dextran sulfate sodium (DSS) model of colitis, macroscopic colon observations demonstrated that P2281 significantly inhibited DSS-induced weight loss, improved rectal bleeding index, decreased disease activity index, and reversed DSS-induced shortening of the colon.


Price and Availability

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Price

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P-2281 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561298
Name: P-2281
CAS#: 1112994-35-0
Chemical Formula: C9H8ClN3O
Exact Mass: 209.0356
Molecular Weight: 209.63
Elemental Analysis: C, 51.57; H, 3.85; Cl, 16.91; N, 20.05; O, 7.63


Synonym: P-2281; P2281; P 2281;

IUPAC/Chemical Name: 2-Chloro-N-(6-cyanopyridin-3-yl)propanamide

InChi Key: VFOLQYOVUCHHET-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H8ClN3O/c1-6(10)9(14)13-8-3-2-7(4-11)12-5-8/h2-3,5-6H,1H3,(H,13,14)

SMILES Code: CC(Cl)C(NC1=CC=C(C#N)N=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: AbuRahma AF, Abu-Halimah S, Hass SM, Nanjundappa A, Stone PA, Mousa A, Lough E, Dean LS. Carotid artery stenting outcomes are equivalent to carotid endarterectomy outcomes for patients with post-carotid endarterectomy stenosis. J Vasc Surg. 2010 Nov;52(5):1180-7. doi: 10.1016/j.jvs.2010.06.074. Epub 2010 Aug 8. PubMed PMID: 20692794.

2: Bhonde MR, Gupte RD, Dadarkar SD, Jadhav MG, Tannu AA, Bhatt P, Bhatia DR, Desai NK, Deore V, Yewalkar N, Vishwakarma RA, Sharma S, Kumar S, Dagia NM. A novel mTOR inhibitor is efficacious in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1237-45. doi: 10.1152/ajpgi.90537.2008. Epub 2008 Oct 16. PubMed PMID: 18927209.