A 204

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571076

CAS#: 12750-79-7

Description: A 204 is a polycyclic polyether monocarboxylic acid antibiotic. It is a crystalline isolated from fermentation of strain of Streptomyces albus.


Price and Availability

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A 204 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571076
Name: A 204
CAS#: 12750-79-7
Chemical Formula: C49H84O17
Exact Mass: 944.5709
Molecular Weight: 945.19
Elemental Analysis: C, 62.27; H, 8.96; O, 28.78


Synonym: A 204; A204; A-204; Antibiotic A 204; Antibiotic A-204; Antibiotic A204

IUPAC/Chemical Name: 2-(2-hydroxy-6-((2-(5'-(6-hydroxy-4-methoxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)octahydro-[2,2'-bifuran]-5-yl)-3,9-dimethoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-5-methoxy-4-((5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)propanoic acid

InChi Key: RHDSQRNKIIRGBB-UHFFFAOYSA-N

InChi Code: InChI=1S/C49H84O17/c1-24-40(56-13)26(3)47(10,52)65-41(24)35-17-16-33(60-35)34-18-20-37(61-34)46(9)42(57-14)28(5)49(66-46)25(2)36(55-12)22-31(63-49)23-38-45(8,58-15)43(27(4)48(53,64-38)29(6)44(50)51)62-39-21-19-32(54-11)30(7)59-39/h24-43,52-53H,16-23H2,1-15H3,(H,50,51)

SMILES Code: COC1CCC(OC2C(C)C(O)(OC(CC3CC(OC)C(C)C4(O3)OC(C)(C5CCC(O5)C6CCC(O6)C7OC(C)(O)C(C)C(OC)C7C)C(OC)C4C)C2(C)OC)C(C)C(=O)O)OC1C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Fitzgerald PR. Efficacy of antibiotics A204 sodium A28695A, and A204np against Coccidia of rabbits. J Protozool. 1976 Feb;23(1):150-4. PubMed PMID: 1271305.

2: Wong DT, Horng JS, Hamill RL, Lardy HA. Effect of a new monocarboxylic acid antibiotic, A204, on the monovalent cation permeability of rat liver mitochondria. Biochem Pharmacol. 1971 Nov;20(11):3169-77. PubMed PMID: 4257133.

3: Worth HM, Meyers DB, Gibson WR, Todd GC. Acute and subacute toxicity of A204. Antimicrob Agents Chemother (Bethesda). 1970;10:357-60. PubMed PMID: 5521356.

4: Todd GC, Meyers DB, Pierce EC, Worth HM. Acute reversible myopathy produced by compound A204. Antimicrob Agents Chemother (Bethesda). 1970;10:361-5. PubMed PMID: 5521357.

5: Meyers DB, Todd GC, Gibson WR. Evidence of depletion of intracellular potassium by A204 in the rat. Antimicrob Agents Chemother (Bethesda). 1970;10:91-4. PubMed PMID: 5521379.

6: Griffing WJ, Todd GC, Pierce EC. Ultrastructural changes in rat skeletal and cardiac muscle induced by A204. Antimicrob Agents Chemother (Bethesda). 1970;10:366-73. PubMed PMID: 5521358.