QC6352

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571057

CAS#: 1851373-36-8

Description: QC6352 is a potent KDM4 family inhibitor that is efficacious in breast and colon cancer PDX models. QC6352 demonstrated an IC50 of 5 nM in BR0869f after a 5-day incubation, and an IC50 of 13 nM in the SU60 model. as excellent physical properties and drug-like characteristics. QC6352 showed favorable in vivo efficacy in a breast cancer PDX model and reduced the tumor initiating cell populations, which are associated with resistance to chemotherapy treatments.


Price and Availability

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QC6352 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571057
Name: QC6352
CAS#: 1851373-36-8
Chemical Formula: C24H25N3O2
Exact Mass: 387.1947
Molecular Weight: 387.483
Elemental Analysis: C, 74.39; H, 6.50; N, 10.84; O, 8.26


Synonym: QC6352; QC-6352; QC 6352.

IUPAC/Chemical Name: (R)-3-(((6-(methyl(phenyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)amino)isonicotinic acid

InChi Key: XSMABFRQESMONQ-SFHVURJKSA-N

InChi Code: InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1

SMILES Code: O=C(O)C1=CC=NC=C1NC[C@@H]2CCCC3=C2C=CC(N(C)C4=CC=CC=C4)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

KDM4 genes and proteins are overexpressed in numerous tumor types including breast, colorectal, pancreatic, lymphoma, and gastric cancers. KDM4 family members also play an important role in the epigenetic regulation of embryonic stem cell identity.


References

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00220
Young K. Chen,† Tiziana Bonaldi,# Alessandro Cuomo,# Joselyn R. Del Rosario,† David J. Hosfield,§
Toufike Kanouni,† Shih-chu Kao,‡,● Chon Lai,† Neethan A. Lobo,‡ Jennifer Matuszkiewicz,†
Andrew McGeehan,‡ Shawn M. O’Connell,†,▲ Lihong Shi,† Jeffrey A. Stafford,†,■ Ryan K. Stansfield,†,■
James M. Veal,†,■ Michael S. Weiss,‡,□ Natalie Y. Yuen,‡ and Michael B. Wallace*,†
†Celgene Quanticel Research, 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States
‡Celgene Quanticel Research, 1500 Owens Street, Suite 500, San Francisco, California 94158, United States
#Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy
§Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States