MDK-0738

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MedKoo CAT#: 561248

CAS#: 56600-73-8 (racemic)

Description: MDK-0738, also known as AKR1C3-IN-14a, is a potent and selective aldo-keto reductase 1C3 inhibitor. The name MDK-0738 uses the last four digits of the CAS registry number for this compound. MDK-0738 displays selectivity for AKR1C3 over other AKR1C enzymes and COX.

Chemical Structure

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MDK-0738
CAS# 56600-73-8 (racemic)
Instruction

Theoretical Analysis

MedKoo Cat#: 561248
Name: MDK-0738
CAS#: 56600-73-8 (racemic)
Chemical Formula: C15H16O3
Exact Mass: 244.11
Molecular Weight: 244.290
Elemental Analysis: C, 73.75; H, 6.60; O, 19.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 56600-73-8 (racemic)  

Synonym: MDK-0738; MDK-0738; MDK-0738; AKR1C3-IN-14a; AKR1C3 IN 14a

IUPAC/Chemical Name: (R)-2-(6-Methoxynaphthalen-2-yl)butanoic acid

InChi Key: LSDAHSHHKKHOKE-CQSZACIVSA-N

InChi Code: InChI=1S/C15H16O3/c1-3-14(15(16)17)12-5-4-11-9-13(18-2)7-6-10(11)8-12/h4-9,14H,3H2,1-2H3,(H,16,17)/t14-/m1/s1

SMILES Code: CC[C@H](C1=CC=C2C=C(OC)C=CC2=C1)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Adeniji A, Uddin MJ, Zang T, Tamae D, Wangtrakuldee P, Marnett LJ, Penning TM. Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. J Med Chem. 2016 Aug 25;59(16):7431-44. doi: 10.1021/acs.jmedchem.6b00160. Epub 2016 Aug 12. PubMed PMID: 27486833; PubMed Central PMCID: PMC5149398.