WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571037

CAS#: 185049-54-1

Description: A-176120 derives from a novel chemical series of potent farnesyl pyrophosphate (FPP) analogues which selectively inhibit farnesyltransferase. A-176120 selectively inhibits farnesyltransferase activity over other closely related enzymes. It has anti-angiogenic potential and may reduce H-ras NIH3T3 tumour growth. A-176120 is a potent FPP mimetic with both antitumour and anti-angiogenic potential.

Price and Availability




A-176120 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 571037
Name: A-176120
CAS#: 185049-54-1
Chemical Formula: C33H29NO9
Exact Mass: 583.1842
Molecular Weight: 583.59
Elemental Analysis: C, 67.92; H, 5.01; N, 2.40; O, 24.67

Synonym: A-176120; A 176120; A 176120

IUPAC/Chemical Name: 5-((2-ethoxybenzyl)(3-(p-tolyloxy)benzyl)carbamoyl)benzene-1,2,4-tricarboxylic acid


InChi Code: 1S/C33H29NO9/c1-3-42-29-10-5-4-8-22(29)19-34(18-21-7-6-9-24(15-21)43-23-13-11-20(2)12-14-23)30(35)25-16-27(32(38)39)28(33(40)41)17-26(25)31(36)37/h4-17H,3,18-19H2,1-2H3,(H,36,37)(H,38,39)(H,40,41)

SMILES Code: CCOc1ccccc1CN(Cc2cccc(c2)Oc3ccc(cc3)C)C(=O)c4cc(c(cc4C(=O)O)C(=O)O)C(=O)O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Tahir SK, Gu WZ, Zhang HC, Leal J, Lee JY, Kovar P, Saeed B, Cherian SP, Devine E, Cohen J, Warner R, Wang YC, Stout D, Arendsen DL, Rosenberg S, Ng SC. Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue. Eur J Cancer. 2000 Jun;36(9):1161-70. PubMed PMID: 10854950.