JG-48

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561235

CAS#: 1627122-26-2

Description: JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in Tau-overexpressing HeLa cells, endogenous Tau in neuroblastoma cells, and endogenous Tau in primary neurons from rTg4510 mice, a mouse model of Alzheimer’s disease


Price and Availability

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JG-48 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561235
Name: JG-48
CAS#: 1627122-26-2
Chemical Formula: C20H16F3N3OS2
Exact Mass: 435.0687
Molecular Weight: 435.48
Elemental Analysis: C, 55.16; H, 3.70; F, 13.09; N, 9.65; O, 3.67; S, 14.72


Synonym: JG-48; JG48; JG 48

IUPAC/Chemical Name: (2Z,5E)-3-Ethyl-5-[3-methyl-6-(trifluoromethyl)-2(3H)-benzothiazolylidene]-2-(2-pyridinylmethylene)-4-thiazolidinone

InChi Key: AWHRSRSTZWQWDX-PZCBVGOASA-N

InChi Code: InChI=1S/C20H16F3N3OS2/c1-3-26-16(11-13-6-4-5-9-24-13)29-17(18(26)27)19-25(2)14-8-7-12(20(21,22)23)10-15(14)28-19/h4-11H,3H2,1-2H3/b16-11-,19-17+

SMILES Code: O=C1N(CC)/C(S/C1=C2SC3=CC(C(F)(F)F)=CC=C3N/2C)=C/C4=NC=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. PubMed PMID: 23607970; PubMed Central PMCID: PMC3740016.