A 1110U

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571015

CAS#: 96860-23-0

Description: A 1110U is an inactivator of herpes simplex virus ribonucloetide reductases. It has been shown to be synergistic with acyclovir to produce chemotherapeutic effects on herpes skin lesions.


Price and Availability

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A 1110U is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571015
Name: A 1110U
CAS#: 96860-23-0
Chemical Formula: C11H16N6S2
Exact Mass: 296.0878
Molecular Weight: 296.41
Elemental Analysis: C, 44.57; H, 5.44; N, 28.35; S, 21.63


Synonym: A 1110U, A-1110U, A1110U

IUPAC/Chemical Name: Carbonathioic dihydrazide, 2-((dimethylamino)thioxomethyl)-2'-(1-(2-pyridinyl)ethylidene)-

InChi Key: RPMMBVWROKDIKM-MDWZMJQESA-N

InChi Code: InChI=1S/C11H16N6S2/c1-8(9-6-4-5-7-12-9)13-14-10(18)15-16-11(19)17(2)3/h4-7H,1-3H3,(H,16,19)(H2,14,15,18)/b13-8+

SMILES Code: S=C(N/N=C(C1=NC=CC=C1)\C)NNC(N(C)C)=S


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Porter DJ, Harrington JA, Spector T. Herpes simplex virus type 1
ribonucleotide reductase: selective and synergistic inactivation by A1110U and
its iron complex. Biochem Pharmacol. 1990 Feb 15;39(4):639-46. PubMed PMID:
2154988.

2: Ellis MN, Lobe DC, Spector T. Synergistic therapy by acyclovir and A1110U for
mice orofacially infected with herpes simplex viruses. Antimicrob Agents
Chemother. 1989 Oct;33(10):1691-6. PubMed PMID: 2556074; PubMed Central PMCID:
PMC172739.

3: Spector T, Harrington JA, Porter DJ. Herpes and human ribonucleotide
reductases. Inhibition by 2-acetylpyridine
5-[(2-chloroanilino)-thiocarbonyl]-thiocarbonohydrazone (348U87). Biochem
Pharmacol. 1991 Jun 21;42(1):91-6. PubMed PMID: 1648925.

4: Spector T, Harrington JA, Morrison RW Jr, Lambe CU, Nelson DJ, Averett DR,
Biron K, Furman PA. 2-Acetylpyridine
5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent
inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster
viruses and a potentiator of acyclovir. Proc Natl Acad Sci U S A. 1989
Feb;86(3):1051-5. PubMed PMID: 2536930; PubMed Central PMCID: PMC286619.

5: Lobe DC, Spector T, Ellis MN. Synergistic topical therapy by acyclovir and
A1110U for herpes simplex virus induced zosteriform rash in mice. Antiviral Res.
1991 Feb;15(2):87-100. PubMed PMID: 1650166.

6: Spector T, Lobe DC, Ellis MN, Blumenkopf TA, Szczech GM. Inactivators of
herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo
potentiation of the antiviral activity of acyclovir. Antimicrob Agents Chemother.
1992 May;36(5):934-7. PubMed PMID: 1324641; PubMed Central PMCID: PMC188768.