K118

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561207

CAS#: 54156-23-9

Description: K118 is a water soluble inhibitor of SH2-containing inositol 5' phosphatase 1 (SHIP1). K118 reverses age- and diet-associated obesity and metabolic syndrome.


Price and Availability

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Price

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K118 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561207
Name: K118
CAS#: 54156-23-9
Chemical Formula: C19H34ClN
Exact Mass: 311.238
Molecular Weight: 311.94
Elemental Analysis: C, 73.16; H, 10.99; Cl, 11.36; N, 4.49


Synonym: K118; K 118; K-118

IUPAC/Chemical Name: (3ß,5α)-Androstan-3-amine hydrochloride

InChi Key: YRFZFBDCFRITSB-NKPAQCGESA-N

InChi Code: InChI=1S/C19H33N.ClH/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18;/h13-17H,3-12,20H2,1-2H3;1H/t13-,14-,15-,16-,17-,18-,19-;/m0./s1

SMILES Code: N[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@@]4(C)[C@H]3CCC4)C1.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Brooks R, Iyer S, Akada H, Neelam S, Russo CM, Chisholm JD, Kerr WG. Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi. Stem Cells. 2015 Mar;33(3):848-58. doi: 10.1002/stem.1902. PubMed PMID: 25402778.

2: Srivastava N, Iyer S, Sudan R, Youngs C, Engelman RW, Howard KT, Russo CM, Chisholm JD, Kerr WG. A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome. JCI Insight. 2016 Jul 21;1(11). pii: e88544. PubMed PMID: 27536730; PubMed Central PMCID: PMC4985248.