Kahweol Acetate
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MedKoo CAT#: 540247

CAS#: 81760-47-6 (Kahweol acetate)

Description: Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.


Price and Availability

Size
Price

10mg
USD 425
Size
Price

25mg
USD 700
Size
Price

Kahweol Acetate purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 540247
Name: Kahweol Acetate
CAS#: 81760-47-6 (Kahweol acetate)
Chemical Formula: C22H28O4
Exact Mass: 356.1988
Molecular Weight: 356.46
Elemental Analysis: C, 74.13; H, 7.92; O, 17.95


Related CAS #: 81760-47-6 (Kahweol acetate)   6894-43-5 (Kahweol)    

Synonym: Kahweol acetate; CCRIS 1520; CCRIS1520; CCRIS-1520

IUPAC/Chemical Name: ((3bS,5aR,7R,8S,10aR,10bS)-7-hydroxy-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b-decahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-yl)methyl acetate

InChi Key: OJLWVPDNBQAHRT-RWKVYSHYSA-N

InChi Code: InChI=1S/C22H28O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h6-8,10,15,17,19,24H,3-5,9,11-13H2,1-2H3/t15-,17+,19-,20+,21+,22-/m0/s1

SMILES Code: CC(OC[C@@]([C@@]1([H])CC2)(O)C[C@@](CC[C@@]34[H])(C1)[C@]2([H])[C@]3(C)C=CC5=C4C=CO5)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lam LK, Yee C, Chung A, Wattenberg LW. Use of silver nitrate impregnated
silica cartridges in the separation of kahweol and cafestol esters by preparative
liquid chromatography. J Chromatogr. 1985 Jun 28;328:422-4. PubMed PMID: 2993334.