Inz-1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561206

CAS#: 897776-15-7

Description: Inz-1 is a fungal-selective inhibitor of mitochondrial cytochrome bc1.

Chemical Structure

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Inz-1
CAS# 897776-15-7
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561206
Name: Inz-1
CAS#: 897776-15-7
Chemical Formula: C16H14N2O2
Exact Mass: 266.11
Molecular Weight: 266.300
Elemental Analysis: C, 72.17; H, 5.30; N, 10.52; O, 12.02

Price and Availability

Size Price Availability Quantity
25mg USD 650 2 Weeks
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Synonym: Inz-1; Inz1; Inz 1

IUPAC/Chemical Name: 3-Phenyl-1H-indazole-1-acetic acid methyl ester

InChi Key: RBYOCUDWQCQSAM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N2O2/c1-20-15(19)11-18-14-10-6-5-9-13(14)16(17-18)12-7-3-2-4-8-12/h2-10H,11H2,1H3

SMILES Code: O=C(OC)CN1N=C(C2=CC=CC=C2)C3=C1C=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 266.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Benjamin M. Vincent, Jean-Baptiste Langlois, Raja Srinivas, Alex K. Lancaster, Ruth Scherz-Shouval, Luke Whitesell, Bruce Tidor, Stephen L. Buchwald, Susan Lindquist. A Fungal-Selective Cytochrome bc1
Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chemical Biology, Volume 23.