A110

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561197

CAS#: 1185388-35-5

Description: A110 is a potent and selective inhibitor of IMPDHs. A110 binds to the NAD(+) cofactor site and forms a ternary complex with IMP.


Price and Availability

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Price

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A110 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561197
Name: A110
CAS#: 1185388-35-5
Chemical Formula: C19H15ClN4O2
Exact Mass: 366.0884
Molecular Weight: 366.81
Elemental Analysis: C, 62.22; H, 4.12; Cl, 9.66; N, 15.27; O, 8.72


Synonym: A110; A 110; A-110

IUPAC/Chemical Name: (R)-4-(1-(1-(4-Chlorophenyl)-1H-1,2,3-triazol-4-yl)ethoxy)quinoline 1-oxide

InChi Key: SVKHERCOWKMPQO-CYBMUJFWSA-N

InChi Code: InChI=1S/C19H15ClN4O2/c1-13(17-12-23(22-21-17)15-8-6-14(20)7-9-15)26-19-10-11-24(25)18-5-3-2-4-16(18)19/h2-13H,1H3/t13-/m1/s1

SMILES Code: C[C@H](C1=CN(C2=CC=C(Cl)C=C2)N=N1)OC3=C4C=CC=CC4=[N+]([O-])C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wei Y, Kuzmič P, Yu R, Modi G, Hedstrom L. Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics. Biochemistry. 2016 Sep 20;55(37):5279-88. doi: 10.1021/acs.biochem.6b00265. Epub 2016 Sep 2. PubMed PMID: 27541177; PubMed Central PMCID: PMC5524190.