Ibotenic Acid
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561191

CAS#: 2552-55-8

Description: Ibotenic Acid is a potent excitatory amino acid agonist. Ibotenic Acid causes motor depression, ataxia, and changes in mood. Ibotenic Acid is also a neurotoxin.


Price and Availability

Size
Price

5mg
USD 360
Size
Price

25mg
USD 1000
Size
Price

Ibotenic Acid, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561191
Name: Ibotenic Acid
CAS#: 2552-55-8
Chemical Formula: C5H6N2O4
Exact Mass: 158.0328
Molecular Weight: 158.11
Elemental Analysis: C, 37.98; H, 3.83; N, 17.72; O, 40.47


Synonym: Ibotenic Acid; Ibotenate

IUPAC/Chemical Name: 2-Amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid

InChi Key: IRJCBFDCFXCWGO-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

SMILES Code: O=C(O)C(N)C(ON1)=CC1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Stebelska K. Fungal hallucinogens psilocin, ibotenic acid, and muscimol: analytical methods and biologic activities. Ther Drug Monit. 2013 Aug;35(4):420-42. doi: 10.1097/FTD.0b013e31828741a5. Review. PubMed PMID: 23851905.

2: Krogsgaard-Larsen P, Honoré T, Hansen JJ, Curtis DR, Lodge D. Structure-activity studies on ibotenic acid and related muscimol analogues. Adv Biochem Psychopharmacol. 1981;27:285-94. Review. PubMed PMID: 7004116.

3: Dunnett SB, Isacson O, Sirinathsinghji DJ, Clarke DJ, Björklund A. Striatal grafts in the ibotenic acid-lesioned neostriatum: functional studies. Prog Brain Res. 1988;78:39-45. Review. PubMed PMID: 3073422.

4: Gressens P, Marret S, Evrard P. Developmental spectrum of the excitotoxic cascade induced by ibotenate: a model of hypoxic insults in fetuses and neonates. Neuropathol Appl Neurobiol. 1996 Dec;22(6):498-502. Review. PubMed PMID: 9004236.

5: Iseki S. [Clinical toxicology of mushroom poisoning. Amanita pantherina, Amanita ibotengutake]. Chudoku Kenkyu. 2013 Sep;26(3):219-22. Review. Japanese. PubMed PMID: 24224385.

6: Luhmann HJ. Models of cortical malformation--Chemical and physical. J Neurosci Methods. 2016 Feb 15;260:62-72. doi: 10.1016/j.jneumeth.2015.03.034. Epub 2015 Apr 4. Review. PubMed PMID: 25850077.

7: Jhamandas KH, Boegman RJ, Beninger RJ. The 1993 Upjohn Award Lecture. Quinolinic acid induced brain neurotransmitter deficits: modulation by endogenous excitotoxin antagonists. Can J Physiol Pharmacol. 1994 Dec;72(12):1473-82. Review. PubMed PMID: 7736338.

8: Hansen JJ, Krogsgaard-Larsen P. Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors. Med Res Rev. 1990 Jan-Mar;10(1):55-94. Review. PubMed PMID: 2153264.

9: Takeuchi H. Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters. Comp Biochem Physiol C. 1992 Sep;103(1):1-12. Review. PubMed PMID: 1360362.

10: Yoneda Y. [Receptive mechanisms of excitatory amino acid signals]. Yakugaku Zasshi. 1993 Jul;113(7):469-88. Review. Japanese. PubMed PMID: 7690072.

11: Krogsgaard-Larsen P, Wahl P, Schousboe A, Madsen U, Hansen JJ. Excitatory amino acid research in Alzheimer's disease: enhancement and blockade of receptor functions. Biochem Soc Trans. 1993 Feb;21(1):102-6. Review. PubMed PMID: 7680619.

12: Kaneko I, Kubo T, Morimoto K. [Neurotoxicity of beta-amyloid]. Nihon Yakurigaku Zasshi. 2000 Feb;115(2):67-77. Review. Japanese. PubMed PMID: 10876793.

13: Krogsgaard-Larsen P, Hansen JJ. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett. 1992 Dec;64-65 Spec No:409-16. Review. PubMed PMID: 1335179.

14: Dunnett SB, Everitt BJ, Robbins TW. The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions. Trends Neurosci. 1991 Nov;14(11):494-501. Review. PubMed PMID: 1726766.

15: Rasia-Filho AA, Haas D, de Oliveira AP, de Castilhos J, Frey R, Stein D, Lazzari VM, Back F, Pires GN, Pavesi E, Winkelmann-Duarte EC, Giovenardi M. Morphological and functional features of the sex steroid-responsive posterodorsal medial amygdala of adult rats. Mini Rev Med Chem. 2012 Oct;12(11):1090-106. Review. PubMed PMID: 22827219.

16: Šaponjić J. [Selective stimulations and lesions of the rat brain nuclei as the models for research of the human sleep pathology mechanisms]. Glas Srp Akad Nauka Med. 2011;(51):85-97. Review. Serbian. PubMed PMID: 22165729.

17: Robbins TW, Everitt BJ. Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems. Neuropharmacology. 1987 Jul;26(7B):893-901. Review. PubMed PMID: 3116447.

18: Halpern JH. Hallucinogens and dissociative agents naturally growing in the United States. Pharmacol Ther. 2004 May;102(2):131-8. Review. PubMed PMID: 15163594.

19: Coote JH. Cardiovascular function of the paraventricular nucleus of the hypothalamus. Biol Signals. 1995 May-Jun;4(3):142-9. Review. PubMed PMID: 8750940.

20: Schliebs R, Rossner S, Bigl V. Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction. Prog Brain Res. 1996;109:253-64. Review. PubMed PMID: 9009714.