WB403

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561188

CAS#: 1594041-84-5

Description: WB403 is a TGR5 activator. WB403 significantly improves glucose tolerance and decreases fasting blood glucose, postprandial blood glucose and HbA1c in type 2 diabetic mice. WB403 also increases pancreatic β-cells and restores the normal distribution pattern of α-cell and β-cell in islets.


Price and Availability

Size
Price

Size
Price

Size
Price

WB403 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 561188
Name: WB403
CAS#: 1594041-84-5
Chemical Formula: C19H19BrN2OS
Exact Mass: 402.0401
Molecular Weight: 403.338
Elemental Analysis: C, 56.58; H, 4.75; Br, 19.81; N, 6.95; O, 3.97; S, 7.95


Synonym: WB403 ; WB-403; WB 403

IUPAC/Chemical Name: 4-(5-((4-Bromobenzyloxy)-methyl)-4-methylthiazol-2-yl)-2-ethylpyridine

InChi Key: NYKBJEUCSJOODJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H19BrN2OS/c1-3-17-10-15(8-9-21-17)19-22-13(2)18(24-19)12-23-11-14-4-6-16(20)7-5-14/h4-10H,3,11-12H2,1-2H3

SMILES Code: CCC1=NC=CC(C2=NC(C)=C(COCC3=CC=C(Br)C=C3)S2)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zheng C, Zhou W, Wang T, You P, Zhao Y, Yang Y, Wang X, Luo J, Chen Y, Liu M, Chen H. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice. PLoS One. 2015 Jul 24;10(7):e0134051. doi: 10.1371/journal.pone.0134051. eCollection 2015. PubMed PMID: 26208278; PubMed Central PMCID: PMC4514850.