AA10

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561183

CAS#: Unknown

Description: AA10 is a irreversible transglutaminase 2 (TG2) inhibitor.


Price and Availability

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Price

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AA10 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561183
Name: AA10
CAS#: Unknown
Chemical Formula: C32H36N4O5
Exact Mass: 556.2686
Molecular Weight: 556.663
Elemental Analysis: C, 69.05; H, 6.52; N, 10.06; O, 14.37


Synonym: AA10; AA 10; AA-10

IUPAC/Chemical Name: (S)-Benzyl (1-(4-(2-naphthoyl)piperazin-1-yl)-6-acrylamido-1-oxohexan-2-yl)carbamate

InChi Key: LCWXTWXQACZEKA-NDEPHWFRSA-N

InChi Code: InChI=1S/C32H36N4O5/c1-2-29(37)33-17-9-8-14-28(34-32(40)41-23-24-10-4-3-5-11-24)31(39)36-20-18-35(19-21-36)30(38)27-16-15-25-12-6-7-13-26(25)22-27/h2-7,10-13,15-16,22,28H,1,8-9,14,17-21,23H2,(H,33,37)(H,34,40)/t28-/m0/s1

SMILES Code: O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(C=C)=O)C(N2CCN(C(C3=CC=C4C=CC=CC4=C3)=O)CC2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Simultaneous analysis of enzyme structure and activity by kinetic capillary electrophoresis–MS. Gleb G Mironov, Christopher M Clouthier, Abdullah Akbar, Jeffrey W Keillor, Maxim V Berezovski. Nature Chemical Biology 12, 918–922 (2016) doi:10.1038/nchembio.2170