L-749329

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561167

CAS#: 159590-37-1

Description: L-749329 is a dual ET(A)/ET(B) endothelin receptor ligand.

Chemical Structure

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L-749329
CAS# 159590-37-1
Instruction

Theoretical Analysis

MedKoo Cat#: 561167
Name: L-749329
CAS#: 159590-37-1
Chemical Formula: C28H29NO8S
Exact Mass: 539.16
Molecular Weight: 539.600
Elemental Analysis: C, 62.33; H, 5.42; N, 2.60; O, 23.72; S, 5.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L-749329; L749329; L 749329

IUPAC/Chemical Name: 4-[1-(1,3-Benzodioxol-5-yl)-2-oxo-2-[(4-propan-2-ylphenyl)sulfonylamino]ethoxy]-3-propylbenzoic acid

InChi Key: JPPYWKVKLSBQJM-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H29NO8S/c1-4-5-19-14-21(28(31)32)9-12-23(19)37-26(20-8-13-24-25(15-20)36-16-35-24)27(30)29-38(33,34)22-10-6-18(7-11-22)17(2)3/h6-15,17,26H,4-5,16H2,1-3H3,(H,29,30)(H,31,32)

SMILES Code: O=C(O)C1=CC=C(OC(C2=CC=C(OCO3)C3=C2)C(NS(=O)(C4=CC=C(C(C)C)C=C4)=O)=O)C(CCC)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 539.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Maguire JJ, Kuc RE, Davenport AP. Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues. Life Sci. 2012 Oct 15;91(13-14):681-6. doi: 10.1016/j.lfs.2012.05.008. Epub 2012 May 23. PubMed PMID: 22634326.

2: Huckle WR, Drag MD, Acker WR, Powers M, McFall RC, Holder DJ, Walsh TF, Schwartz RS, Greenlee WJ, Johnson RG Jr. Effects of L-749,329, an ET(A)/ET(B) endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation. 2001 Apr 10;103(14):1899-905. PubMed PMID: 11294810.

3: Hara M, Tozawa F, Itazaki K, Mihara S, Fujimoto M. Endothelin ET(B) receptors show different binding profiles in intact cells and cell membrane preparations. Eur J Pharmacol. 1998 Mar 26;345(3):339-42. PubMed PMID: 9592035.

4: Wu-Wong JR, Chiou WJ, Hoffman DJ, Winn M, von Geldern TW, Opgenorth TJ. Endothelins and endothelin receptor antagonists: binding to plasma proteins. Life Sci. 1996;58(21):1839-47. PubMed PMID: 8637410.

5: Iwasaki T, Mihara S, Shimamura T, Kawakami M, Masui M, Hayasaki-Kajiwara Y, Naya N, Ninomiya M, Fujimoto M, Nakajima M. Pharmacologic characterization of S-1255, a highly potent and orally active endothelin A receptor antagonist. J Cardiovasc Pharmacol. 2001 Apr;37(4):471-82. PubMed PMID: 11300660.

6: Wu-Wong JR, Dixon DB, Chiou WJ, Opgenorth TJ. Endothelin receptor antagonists: effect of serum albumin on potency and comparison of pharmacological characteristics. J Pharmacol Exp Ther. 1997 May;281(2):791-8. PubMed PMID: 9152387.