PA1 2HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561161

CAS#: 1620951-72-5 (free base)

Description: PA1 2HCl is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 2HCl enables the optical control of ENaC channels, in particular the δβγ isoform, by switching between blue and green light, or by turning on and off blue light. PA1 2HCl was used to modify functionally δβγENaC in amphibian and mammalian cells.


Price and Availability

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PA1 2HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561161
Name: PA1 2HCl
CAS#: 1620951-72-5 (free base)
Chemical Formula: C18H18Cl3N9O
Exact Mass:
Molecular Weight: 482.75
Elemental Analysis: C, 44.78; H, 3.76; Cl, 22.03; N, 26.11; O, 3.31


Synonym: PA1 2HCl; PA1 dihydrochloride; PA1

IUPAC/Chemical Name: 3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamide dihydrochloride

InChi Key: JKZVQNCSFUAMFC-JZYARHMISA-N

InChi Code: InChI=1S/C18H16ClN9O.2ClH/c19-14-16(21)25-15(20)13(24-14)17(29)26-18(22)23-10-6-8-12(9-7-10)28-27-11-4-2-1-3-5-11;;/h1-9H,(H4,20,21,25)(H3,22,23,26,29);2*1H/b28-27+;;

SMILES Code: O=C(C1=NC(Cl)=C(N)N=C1N)NC(NC2=CC=C(/N=N/C3=CC=CC=C3)C=C2)=N.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Schönberger M, Althaus M, Fronius M, Clauss W, Trauner D. Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat Chem. 2014 Aug;6(8):712-9. doi: 10.1038/nchem.2004. Epub 2014 Jul 20. PubMed PMID: 25054942.