MDK-3017
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561146

CAS#: 84783-01-7

Description: MDK-3017, also known as K-Ras-IN-2 or K-Ras Inhibitor-2, is a small molecule K-Ras inhibitor. The last four digits of the compound's CAS registry number are used in its name. MDK-3017 binds to K-Ras in a hydrophobic pocket occupied by Tyr-71.


Chemical Structure

img
MDK-3017
CAS# 84783-01-7

Theoretical Analysis

MedKoo Cat#: 561146
Name: MDK-3017
CAS#: 84783-01-7
Chemical Formula: C11H13NOS
Exact Mass: 207.07
Molecular Weight: 207.290
Elemental Analysis: C, 63.74; H, 6.32; N, 6.76; O, 7.72; S, 15.47

Price and Availability

Size Price Availability Quantity
100mg USD 550 2 Weeks
200mg USD 950 2 weeks
500mg USD 1950 2 weeks
1g USD 2850 2 weeks
2g USD 4650 2 weeks
Bulk inquiry

Synonym: MDK-3017; MDK3017; MDK 3017; K-Ras-IN-2; K-Ras Inhibitor-2

IUPAC/Chemical Name: (2-Hydroxy-phenyl)-pyrrolidin-1-yl-methanethione

InChi Key: QIKLOVZAPGSYNO-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H13NOS/c13-10-6-2-1-5-9(10)11(14)12-7-3-4-8-12/h1-2,5-6,13H,3-4,7-8H2

SMILES Code: S=C(C1=CC=CC=C1O)N2CCCC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 207.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Sun Q, Burke JP, Phan J, et al. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation. Angewandte Chemie (International ed in English). 2012;51(25):6140-6143. doi:10.1002/anie.201201358.