G-130

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561072

CAS#: 42013-48-9

Description: G-130, also known as GP-130, is a drug with stimulant and anorectic effects, related to phenmetrazine. Compounds related to G-130 were synthesized that behave as combined inhibitors of monoamine uptake and nAChRs.


Price and Availability

Size
Price

Size
Price

Size
Price

G-130 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 561072
Name: G-130
CAS#: 42013-48-9
Chemical Formula: C12H17NO
Exact Mass: 191.131
Molecular Weight: 191.27
Elemental Analysis: C, 75.35; H, 8.96; N, 7.32; O, 8.36


Synonym: G-130; G 130; G130; GP-130; GP 130; GP130

IUPAC/Chemical Name: 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine

InChi Key: KJUOROGOOZJYAI-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H17NO/c1-12(2)9-14-11(8-13-12)10-6-4-3-5-7-10/h3-7,11,13H,8-9H2,1-2H3

SMILES Code: CC1(C)NCC(C2=CC=CC=C2)OC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Fanelli O (June 1973). "Pharmacological and toxicological study of a new psychotropic stimulant: the 2-phenyl-5-dimethyl-tetrahydro-1,4-oxazine, in comparison with d,l-amphetamine, phenmetrazine and pemoline-Mg". Arzneimittel-Forschung. 23 (6): 810–6. PMID 4740767.

2: Fanelli O, Mazzoncini V, Ferri S (October 1974). "Toxicological and teratological study of 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130), a psychostimulant drug". Arzneimittel-Forschung. 24 (10): 1627–32. PMID 4479774.

3: Fanelli O, Mazzoncini V, Trallori L (December 1974). "Antagonism of psychostimulant 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130) to central nervous system depressing drugs. Monoamine oxidase inhibitory activity and norepinephrine and serotonin induced changes. Comparison with dL-amphetamine". Arzneimittel-Forschung. 24 (12): 2025–9. PMID 4480283.

4: Carroll, F. I.; Muresan, A. Z.; Blough, B. E.; Navarro, H. N. A.; Mascarella, S. W.; Eaton, J. B.; Huang, X.; Damaj, M. I.; Lukas, R. J. (2011). "Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine". Journal of Medicinal Chemistry. 54 (5): 1441–1448. PMC 3048909 Freely accessible. PMID 21319801. doi:10.1021/jm1014555.