Napitane Mesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561068

CAS#: 149189-73-1 (mesylate)

Description: Napitane Mesylate, also known as ABT-200 or A-75200, is a potent alpha 2-adrenoceptor antagonist. Napitane Mesylate binds to CA transporters in the central nervous system and blocks uptake. Napitane Mesylate also blocks norepinephrine uptake by inhibiting the norepinephrine transporter.


Price and Availability

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Napitane Mesylate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561068
Name: Napitane Mesylate
CAS#: 149189-73-1 (mesylate)
Chemical Formula: C23H29NO5S
Exact Mass:
Molecular Weight: 431.547
Elemental Analysis: C, 64.01; H, 6.77; N, 3.25; O, 18.54; S, 7.43


Related CAS #: 148152-63-0 (free base)   149189-73-1 (mesylate)    

Synonym: Napitane Mesylate; ABT-200; A-75200

IUPAC/Chemical Name: (1'R*,3R*)-3-Phenyl-1- [(1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate

InChi Key: IXLOGUKQFISQPX-APTPAJQOSA-N

InChi Code: InChI=1S/C22H25NO2.CH4O3S/c1-2-5-16(6-3-1)17-11-12-23(13-17)14-18-7-4-8-20-19(18)9-10-21-22(20)25-15-24-21;1-5(2,3)4/h1-3,5-6,9-10,17-18H,4,7-8,11-15H2;1H3,(H,2,3,4)/t17-,18-;/m0./s1

SMILES Code: CS(=O)(O)=O.N1(C[C@@H]2CCCC3=C2C=CC4=C3OCO4)C[C@@H](C5=CC=CC=C5)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Cass WA, Friedemann MN, deBernardis JF, Kerkman DJ, Gerhardt GA. Effects of the putative antidepressant, ABT 200, on the clearance of exogenous norepinephrine in rat cerebellum. Synapse. 1995 Sep;21(1):77-84. PubMed PMID: 8525465.

2: Firestone JA, Marks MJ, Gerhardt GA, Browning MD. ABT-200, a norepinephrine uptake inhibitor, blocks Ca2+ signals in chromaffin cells. Eur J Pharmacol. 1994 Oct 14;269(2):177-82. PubMed PMID: 7851493.

3: Hancock AA, Buckner SA, Giardina WJ, Brune ME, Lee JY, Morse PA, Oheim KW, Stanisic DS, Warner RB, Kerkman DJ, et al. Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine. J Pharmacol Exp Ther. 1995 Mar;272(3):1160-9. PubMed PMID: 7891328.

4: Ferrero JL, Thomas SB, Marsh KC, Rodrigues AD, Uchic JT, Buko AM. Implication of P450-metabolite complex formation in the nonlinear pharmacokinetics and metabolic fate of (+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-nap hthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in dogs. Drug Metab Dispos. 2002 Oct;30(10):1094-101. PubMed PMID: 12228185.

5: Magni LR, Purgato M, Gastaldon C, Papola D, Furukawa TA, Cipriani A, Barbui C. Fluoxetine versus other types of pharmacotherapy for depression. Cochrane Database Syst Rev. 2013 Jul 17;(7):CD004185. Review. PubMed PMID: 24353997.

6: Cipriani A, Brambilla P, Furukawa T, Geddes J, Gregis M, Hotopf M, Malvini L, Barbui C. Fluoxetine versus other types of pharmacotherapy for depression. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD004185. Review. Update in: Cochrane Database Syst Rev. 2013;7:CD004185. PubMed PMID: 16235353; PubMed Central PMCID: PMC4163961.

7: Chen J, Rasenick MM. Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content. J Pharmacol Exp Ther. 1995 Oct;275(1):509-17. PubMed PMID: 7562593.