H77-77

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561067

CAS#: 21618-99-5

Description: H77-77 is a monoamine oxidase (MAO) inhibitor. In rats, H77-77 produces a pronounced protection against phenelzine within the serotonergic and noradrenergic neurons.


Price and Availability

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H77-77 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561067
Name: H77-77
CAS#: 21618-99-5
Chemical Formula: C10H15NO
Exact Mass: 165.1154
Molecular Weight: 165.236
Elemental Analysis: C, 72.69; H, 9.15; N, 8.48; O, 9.68


Synonym: H77-77; H77 77; H7777; H77/77

IUPAC/Chemical Name: 5-(2-Aminopropyl)-2-methylphenol

InChi Key: XWLXNPMITZDCHL-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H15NO/c1-7-3-4-9(5-8(2)11)6-10(7)12/h3-4,6,8,12H,5,11H2,1-2H3

SMILES Code: OC1=CC(CC(N)C)=CC=C1C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Fagervall I, Kelder D, Ross SB. Selective inhibition by 4,alpha-dimethyl-m-tyramine (H77/77) and 4-methyl-alpha-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1988 Aug;338(2):143-7. PubMed PMID: 2460774.

2: Fuxe K, Janson AM, Rosén L, Finnman UB, Tanganelli S, Morari M, Goldstein M, Agnati LF. Evidence for a protective action of the vigilance promoting drug modafinil on the MPTP-induced degeneration of the nigrostriatal dopamine neurons in the black mouse: an immunocytochemical and biochemical analysis. Exp Brain Res. 1992;88(1):117-30. PubMed PMID: 1347270.

3: Leonard BE, Shallice SA. Some neurochemical effects of amphetamine, methylamphetamine and p-bromomethylamphetamine in the rat. Br J Pharmacol. 1971 Feb;41(2):198-212. PubMed PMID: 5572273; PubMed Central PMCID: PMC1703283.

4: Maj J, Melzacka M, Mogilnicka E, Daniel W. Different pharmacokinetic and pharmacological effects following acute and chronic treatment with imipramine. J Neural Transm. 1982;54(3-4):219-28. PubMed PMID: 7130974.

5: Lotti VJ, Clineschmidt BV, Haubrich D, Porter CC. 6-Chloro-2(1-piperazinyl) quinoxaline (CPQ): action on serotonin-induced behavioral responses and interactions with chloromethamphetamine and dimethyl-meta-tyramine. Arch Int Pharmacodyn Ther. 1978 Sep;235(1):103-15. PubMed PMID: 153735.

6: Moret C, Charveron M, Finberg JP, Couzinier JP, Briley M. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology. 1985 Dec;24(12):1211-9. PubMed PMID: 3005901.