Enilconazole
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540218

CAS#: 35554-44-0

Description: Enilconazole, also known as Imazalil, is an inhibitor of 14α-demethylase, aromatase, and androgen receptors that inhibits ergosterol synthesis and fungal cell wall formation. It also alters neural differentiation and displays teratogenic effects in vertebrate development.


Chemical Structure

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Enilconazole
CAS# 35554-44-0

Theoretical Analysis

MedKoo Cat#: 540218
Name: Enilconazole
CAS#: 35554-44-0
Chemical Formula: C14H14Cl2N2O
Exact Mass: 296.05
Molecular Weight: 297.170
Elemental Analysis: C, 56.58; H, 4.75; Cl, 23.86; N, 9.43; O, 5.38

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
5g USD 550 2 weeks
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Synonym: Imazalil; Enilconazole; 1-(2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl)-1H-imidazole; Chloramizol;

IUPAC/Chemical Name: 1-(2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

InChi Key: PZBPKYOVPCNPJY-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H14Cl2N2O/c1-2-7-19-14(9-18-6-5-17-10-18)12-4-3-11(15)8-13(12)16/h2-6,8,10,14H,1,7,9H2

SMILES Code: C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kirmizigul AH, Erkilic EE, Buyuk F, Gokce E, Citil M. Efficacy of pomades containing different percentages of enilconazole in the treatment of bovine dermatophytosis. Vet Dermatol. 2016 Jun;27(3):181-e45. doi: 10.1111/vde.12299. Epub 2016 Mar 16. PubMed PMID: 26990840.

2: Sharman M, Lenard Z, Hosgood G, Mansfield C. Clotrimazole and enilconazole distribution within the frontal sinuses and nasal cavity of nine dogs with sinonasal aspergillosis. J Small Anim Pract. 2012 Mar;53(3):161-7. doi: 10.1111/j.1748-5827.2011.01181.x. Epub 2012 Feb 2. PubMed PMID: 22300493.

3: Zonderland JL, Störk CK, Saunders JH, Hamaide AJ, Balligand MH, Clercx CM. Intranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs. J Am Vet Med Assoc. 2002 Nov 15;221(10):1421-5. PubMed PMID: 12458610.

4: Billen F, Guieu LV, Bernaerts F, Mercier E, Lavoué R, Tual C, Peeters D, Clercx C. Efficacy of intrasinusal administration of bifonazole cream alone or in combination with enilconazole irrigation in canine sino-nasal aspergillosis: 17 cases. Can Vet J. 2010 Feb;51(2):164-8. PubMed PMID: 20436862; PubMed Central PMCID: PMC2808281.

5: Mancianti F, Dabizzi S, Nardoni S. A lufenuron pre-treatment may enhance the effects of enilconazole or griseofulvin in feline dermatophytosis? J Feline Med Surg. 2009 Feb;11(2):91-5. doi: 10.1016/j.jfms.2008.05.006. Epub 2008 Aug 5. PubMed PMID: 18684653.

6: Hnilica KA, Medleau L. Evaluation of topically applied enilconazole for the treatment of dermatophytosis in a Persian cattery. Vet Dermatol. 2002 Feb;13(1):23-8. PubMed PMID: 11896967.

7: Kendall A, Bröjer J, Karlstam E, Pringle J. Enilconazole treatment of horses with superficial Aspergillus spp. rhinitis. J Vet Intern Med. 2008 Sep-Oct;22(5):1239-42. doi: 10.1111/j.1939-1676.2008.0173.x. PubMed PMID: 18844830.

8: Sharp NJ, Sullivan M, Harvey CE, Webb T. Treatment of canine nasal aspergillosis with enilconazole. J Vet Intern Med. 1993 Jan-Feb;7(1):40-3. PubMed PMID: 8455182.

9: Claeys S, Lefebvre JB, Schuller S, Hamaide A, Clercx C. Surgical treatment of canine nasal aspergillosis by rhinotomy combined with enilconazole infusion and oral itraconazole. J Small Anim Pract. 2006 Jun;47(6):320-4. PubMed PMID: 16761984.

10: Guillot J, Malandain E, Jankowski F, Rojzner K, Fournier C, Touati F, Chermette R, Seewald W, Schenker R. Evaluation of the efficacy of oral lufenuron combined with topical enilconazole for the management of dermatophytosis in catteries. Vet Rec. 2002 Jun 8;150(23):714-8. PubMed PMID: 12081306.

11: Van Cutsem J. Antifungal activity of enilconazole on experimental Aspergillosis in chickens. Avian Dis. 1983 Jan-Mar;27(1):36-42. PubMed PMID: 6342595.

12: Bray JP, White RA, Lascelles BD. Treatment of canine nasal aspergillosis with a new non-invasive technique. Failure with enilconazole. J Small Anim Pract. 1998 May;39(5):223-6. PubMed PMID: 9631356.

13: Van Cutsem J, Van Gerven F, Geerts H, Rochette F. Treatment with enilconazole spray of dermatophytosis in rabbit farms. Mykosen. 1985 Aug;28(8):400-7. PubMed PMID: 4047095.

14: Talbot JJ, Kidd SE, Martin P, Beatty JA, Barrs VR. Azole resistance in canine and feline isolates of Aspergillus fumigatus. Comp Immunol Microbiol Infect Dis. 2015 Oct;42:37-41. doi: 10.1016/j.cimid.2015.08.002. Epub 2015 Aug 28. PubMed PMID: 26387063.

15: McCullough SM, McKiernan BC, Grodsky BS. Endoscopically placed tubes for administration of enilconazole for treatment of nasal aspergillosis in dogs. J Am Vet Med Assoc. 1998 Jan 1;212(1):67-9. PubMed PMID: 9426780.

16: Sharp NJ, Sullivan M. Treatment of canine nasal aspergillosis with systemic ketoconazole and topical enilconazole. Vet Rec. 1986 May 17;118(20):560-1. PubMed PMID: 3523960.

17: de Keyser H. [Activity of repeated administration of enilconazole (R 23 979) against Trichophyton verrucosum in cattle. A clinical trial (author's transl)]. Tijdschr Diergeneeskd. 1981 Aug 15;106(16):799-805. Dutch. PubMed PMID: 7281154.

18: Desplenter L. Dermatophytosis in small animals: topical treatment and environmental control with enilconazole. Tijdschr Diergeneeskd. 1989 Apr;114 Suppl 1:33S-34S. PubMed PMID: 2749710.

19: Moriello KA. Kennel Disinfectants for Microsporum canis and Trichophyton sp. Vet Med Int. 2015;2015:853937. doi: 10.1155/2015/853937. Epub 2015 Feb 11. PubMed PMID: 25763290; PubMed Central PMCID: PMC4339702.

20: Gogolashvili A, Tatunashvili E, Chankvetadze L, Sohajda T, Szeman J, Salgado A, Chankvetadze B. Separation of enilconazole enantiomers in capillary electrophoresis with cyclodextrin-type chiral selectors and investigation of structure of selector-selectand complexes by using nuclear magnetic resonance spectroscopy. Electrophoresis. 2017 Mar 22. doi: 10.1002/elps.201700078. [Epub ahead of print] PubMed PMID: 28328068.