K6PC-5
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561031

CAS#: 756875-51-1

Description: K6PC-5 is a sphingosine kinase 1 (SphK1) activator.


Price and Availability

Size
Price

5mg
USD 230
Size
Price

25mg
USD 570
Size
Price

K6PC-5, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561031
Name: K6PC-5
CAS#: 756875-51-1
Chemical Formula: C19H37NO4
Exact Mass: 343.2723
Molecular Weight: 343.508
Elemental Analysis: C, 66.43; H, 10.86; N, 4.08; O, 18.63


Synonym: K6PC-5; K6PC 5; K6PC5

IUPAC/Chemical Name: 2-Hexyl-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-oxo-decanamide

InChi Key: CGYVFCHCRBGGJG-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24)

SMILES Code: CCCCCCCC(C(CCCCCC)C(NC(CO)CO)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shao JJ, Peng Y, Wang LM, Wang JK, Chen X. Activation of SphK1 by K6PC-5 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Myocardial Cell Death. DNA Cell Biol. 2015 Nov;34(11):669-76. doi: 10.1089/dna.2015.2959. Epub 2015 Aug 26. PubMed PMID: 26308910; PubMed Central PMCID: PMC4642826.

2: Ji F, Mao L, Liu Y, Cao X, Xie Y, Wang S, Fei H. K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. Biochem Biophys Res Commun. 2015 Mar 13;458(3):568-75. doi: 10.1016/j.bbrc.2015.02.007. Epub 2015 Feb 11. PubMed PMID: 25680461.

3: Kwon YB, Kim CD, Youm JK, Gwak HS, Park BD, Lee SH, Jeon S, Kim BJ, Seo YJ, Park JK, Lee JH. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. Epub 2007 Jun 6. Erratum in: J Lipid Res. 2007 Dec;48(12):2794. PubMed PMID: 17554144.

4: Bernacchioni C, Cencetti F, Kwon MJ, Gwak HS, Jeong SK, Bruni P, Donati C. The sphingosine kinase activator K6PC-5 stimulates C2C12 myoblast differentiation. Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):55-62. PubMed PMID: 21496387.

5: Park HY, Youm JK, Kwon MJ, Park BD, Lee SH, Choi EH. K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. Exp Dermatol. 2008 Oct;17(10):829-36. doi: 10.1111/j.1600-0625.2008.00708.x. Epub 2008 Mar 13. PubMed PMID: 18341573.

6: Hong JH, Youm JK, Kwon MJ, Park BD, Lee YM, Lee SI, Shin DM, Lee SH. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. J Invest Dermatol. 2008 Sep;128(9):2166-78. doi: 10.1038/jid.2008.66. Epub 2008 Apr 3. PubMed PMID: 18385762.

7: Youm JK, Jo H, Hong JH, Shin DM, Kwon MJ, Jeong SK, Park BD, Choi EH, Lee SH. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51(2):89-102. doi: 10.1016/j.jdermsci.2008.03.002. Epub 2008 Apr 16. PubMed PMID: 18420384.

8: Jung M, Lee S, Park HY, Youm JK, Jeong S, Bae J, Kwon MJ, Park BD, Lee SH, Choi EH. Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin. Exp Dermatol. 2011 Apr;20(4):314-9. doi: 10.1111/j.1600-0625.2010.01185.x. Epub 2011 Mar 1. PubMed PMID: 21366697.

9: Xu L, Zhang Y, Gao M, Wang G, Fu Y. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2016 Apr 15;472(4):662-8. doi: 10.1016/j.bbrc.2016.02.094. Epub 2016 Feb 23. PubMed PMID: 26920060.