Ochratoxin A
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MedKoo CAT#: 561027

CAS#: 303-47-9

Description: Ochratoxin A (OTA) is a mycotoxin produced by several fungal species including Aspergillus ochraceus, A. carbonarius, A. niger, and Penicillium verrucosum. Ochratoxin A is one of the most-abundant food-contaminating mycotoxins.


Price and Availability

Size
Price

1mg
USD 200
Size
Price

5mg
USD 440
Size
Price

10mg
USD 810

Ochratoxin A, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561027
Name: Ochratoxin A
CAS#: 303-47-9
Chemical Formula: C20H18ClNO6
Exact Mass: 403.0823
Molecular Weight: 403.815
Elemental Analysis: C, 59.49; H, 4.49; Cl, 8.78; N, 3.47; O, 23.77


Synonym: Ochratoxin A; OTA; Ochratoxin-A;

IUPAC/Chemical Name: ((R)-5-chloro-8-hydroxy-3-methyl-1-oxoisochromane-7-carbonyl)-D-phenylalanine

InChi Key: RWQKHEORZBHNRI-MEBBXXQBSA-N

InChi Code: InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15-/m1/s1

SMILES Code: OC1=C2C(C[C@@H](C)OC2=O)=C(Cl)C=C1C(N[C@@H](C(O)=O)CC3=CC=CC=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bui-Klimke TR, Wu F. Ochratoxin A and human health risk: a review of the evidence. Crit Rev Food Sci Nutr. 2015;55(13):1860-9. doi: 10.1080/10408398.2012.724480. Review. PubMed PMID: 24874522; PubMed Central PMCID: PMC4247821.

2: Khalesi M. Ochratoxin A in liquorice products - a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(12):2086-92. doi: 10.1080/19440049.2015.1094708. Epub 2015 Oct 15. Review. PubMed PMID: 26374697.

3: Heussner AH, Bingle LE. Comparative Ochratoxin Toxicity: A Review of the Available Data. Toxins (Basel). 2015 Oct 22;7(10):4253-82. doi: 10.3390/toxins7104253. Review. PubMed PMID: 26506387; PubMed Central PMCID: PMC4626733.

4: Zhihong L, Kunlun H, Yunbo L. Ochratoxin A and ochratoxin-producing fungi on cereal grain in China: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(4):461-70. doi: 10.1080/19440049.2014.996787. Epub 2015 Jan 9. Review. PubMed PMID: 25571918.

5: Baggiani C, Giovannoli C, Anfossi L. Man-Made Synthetic Receptors for Capture and Analysis of Ochratoxin A. Toxins (Basel). 2015 Oct 10;7(10):4083-98. doi: 10.3390/toxins7104083. Review. PubMed PMID: 26473924; PubMed Central PMCID: PMC4626722.

6: Vettorazzi A, González-Peñas E, de Cerain AL. Ochratoxin A kinetics: a review of analytical methods and studies in rat model. Food Chem Toxicol. 2014 Oct;72:273-88. doi: 10.1016/j.fct.2014.07.020. Epub 2014 Jul 21. Review. PubMed PMID: 25057808.

7: Ha TH. Recent Advances for the Detection of Ochratoxin A. Toxins (Basel). 2015 Dec 4;7(12):5276-300. doi: 10.3390/toxins7124882. Review. PubMed PMID: 26690216; PubMed Central PMCID: PMC4690132.

8: Vettorazzi A, van Delft J, López de Cerain A. A review on ochratoxin A transcriptomic studies. Food Chem Toxicol. 2013 Sep;59:766-83. doi: 10.1016/j.fct.2013.05.043. Epub 2013 Jun 6. Review. PubMed PMID: 23747715.

9: Limonciel A, Jennings P. A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity. Toxins (Basel). 2014 Jan 20;6(1):371-9. doi: 10.3390/toxins6010371. Review. PubMed PMID: 24448208; PubMed Central PMCID: PMC3920267.

10: Malir F, Ostry V, Pfohl-Leszkowicz A, Novotna E. Ochratoxin A: developmental and reproductive toxicity-an overview. Birth Defects Res B Dev Reprod Toxicol. 2013 Dec;98(6):493-502. doi: 10.1002/bdrb.21091. Epub 2014 Jan 6. Review. PubMed PMID: 24395216.

11: Sorrenti V, Di Giacomo C, Acquaviva R, Barbagallo I, Bognanno M, Galvano F. Toxicity of ochratoxin a and its modulation by antioxidants: a review. Toxins (Basel). 2013 Oct 11;5(10):1742-66. doi: 10.3390/toxins5101742. Review. PubMed PMID: 24152986; PubMed Central PMCID: PMC3813909.

12: Bellver Soto J, Fernández-Franzón M, Ruiz MJ, Juan-García A. Presence of ochratoxin A (OTA) mycotoxin in alcoholic drinks from southern European countries: wine and beer. J Agric Food Chem. 2014 Aug 6;62(31):7643-51. doi: 10.1021/jf501737h. Epub 2014 Jul 25. Review. PubMed PMID: 25039256.

13: Ostry V, Malir F, Ruprich J. Producers and important dietary sources of ochratoxin A and citrinin. Toxins (Basel). 2013 Sep 17;5(9):1574-86. doi: 10.3390/toxins5091574. Review. PubMed PMID: 24048364; PubMed Central PMCID: PMC3798874.

14: Zhou WL, Wang YT, Kong WJ, Yang MH, Zhao M, Ou-Yang Z. [Advancement of colloidal gold chromatographic technique in screening of ochratoxin A]. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(15):2945-51. Review. Chinese. PubMed PMID: 26677691.

15: Rhouati A, Yang C, Hayat A, Marty JL. Aptamers: a promosing tool for ochratoxin A detection in food analysis. Toxins (Basel). 2013 Nov 5;5(11):1988-2008. doi: 10.3390/toxins5111988. Review. PubMed PMID: 24196457; PubMed Central PMCID: PMC3847711.

16: Meulenberg EP. Immunochemical methods for ochratoxin A detection: a review. Toxins (Basel). 2012 Apr;4(4):244-66. doi: 10.3390/toxins4040244. Epub 2012 Apr 13. Review. PubMed PMID: 22606375; PubMed Central PMCID: PMC3347002.

17: Petruzzi L, Sinigaglia M, Corbo MR, Campaniello D, Speranza B, Bevilacqua A. Decontamination of ochratoxin A by yeasts: possible approaches and factors leading to toxin removal in wine. Appl Microbiol Biotechnol. 2014 Aug;98(15):6555-67. doi: 10.1007/s00253-014-5814-4. Epub 2014 May 20. Review. PubMed PMID: 24841121.

18: Malir F, Ostry V, Pfohl-Leszkowicz A, Malir J, Toman J. Ochratoxin A: 50 Years of Research. Toxins (Basel). 2016 Jul 4;8(7). pii: E191. doi: 10.3390/toxins8070191. Review. PubMed PMID: 27384585; PubMed Central PMCID: PMC4963825.

19: Kőszegi T, Poór M. Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level. Toxins (Basel). 2016 Apr 15;8(4):111. doi: 10.3390/toxins8040111. Review. PubMed PMID: 27092524; PubMed Central PMCID: PMC4848637.

20: Klarić MS, Rašić D, Peraica M. Deleterious effects of mycotoxin combinations involving ochratoxin A. Toxins (Basel). 2013 Nov 1;5(11):1965-87. doi: 10.3390/toxins5111965. Review. PubMed PMID: 24189375; PubMed Central PMCID: PMC3847710.