Benzoctamine Hydrochloride
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MedKoo CAT#: 561020

CAS#: 10085-81-1 (HCl)

Description: Benzoctamine is a drug that possesses sedative and anxiolytic properties. Medically, benzoctamine is used as a treatment for anxious outpatients to control aggression, enuresis, fear, and minor social maladjustment in children.


Price and Availability

Size
Price

10mg
USD 400
Size
Price

Size
Price

Benzoctamine Hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561020
Name: Benzoctamine Hydrochloride
CAS#: 10085-81-1 (HCl)
Chemical Formula: C18H20ClN
Exact Mass:
Molecular Weight: 285.82
Elemental Analysis: C, 75.64; H, 7.05; Cl, 12.40; N, 4.90


Related CAS #: 10085-81-1 (HCl)   17243-39-9 (free base)   74401-28-8 (mesylayte)    

Synonym: Benzoctamine Hydrochloride; Tacitin; Tacitine

IUPAC/Chemical Name: N-Methyl-9,10-ethanoanthracene-9(10H)-methylamine hydrochloride

InChi Key: NZPJYSIIKYJREH-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19N.ClH/c1-19-12-18-11-10-13(14-6-2-4-8-16(14)18)15-7-3-5-9-17(15)18;/h2-9,13,19H,10-12H2,1H3;1H

SMILES Code: CNCC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Przegaliński E, Baran L, Palider W, Bigajska K. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978 Nov-Dec;30(6):781-90. PubMed PMID: 582625.

2: Lippmann W, Pugsley TA. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974 Aug;51(4):571-5. PubMed PMID: 4480288; PubMed Central PMCID: PMC1778070.

3: McCaughey W, Pandit SK, Morrison JD. Letter: Benzoctamine. Br J Anaesth. 1974 Mar;46(3):189. PubMed PMID: 4604678.

4: Tolksdorf W, Hartung HJ, Kämmerer T, Rohowsky R, Lutz H. [The effect on breathing of flunitrazepam and benzoctamine as adjuvants in spinal anesthesia in broncho-pulmonary risk patients]. Anaesthesist. 1980 Aug;29(8):434-8. German. PubMed PMID: 6107057.

5: Karama U, Sultan MA, Almansour AI, El-Taher KE. Synthesis of Chlorinated Tetracyclic Compounds and Testing for Their Potential Antidepressant Effect in Mice. Molecules. 2016 Jan 5;21(1):61. doi: 10.3390/molecules21010061. PubMed PMID: 26742028.

6: Coelle EF, Osborne NN, Neuhoff V, Sontag KH. Failure of benzoctamine to influence the activity of rat striatum tyrosine-hydroxylase. Arzneimittelforschung. 1976;26(8):1630-1. PubMed PMID: 12774.

7: Zsigmond EK, Flynn K. Effect of benzoctamine on arterial blood gases in healthy volunteers. Clin Ther. 1981;4(2):109-13. PubMed PMID: 6794910.

8: Cohen ML, Fuller RW, Kurz KD. Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats. Hypertension. 1983 Sep-Oct;5(5):676-81. PubMed PMID: 6311738.

9: Clark TJ, Collins JV. Use of benzoctamine as sedative in patients with respiratory failure. Br Med J. 1973 Jan 13;1(5845):75-6. PubMed PMID: 20791872; PubMed Central PMCID: PMC1588741.

10: Jost U, Schmid A, Ruppert M. [Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)]. Anaesthesist. 1982 Jan;31(1):21-4. German. PubMed PMID: 6896119.

11: Bézault G, Chatel B, Dehu J, Jouy JC. [Trial of benzoctamine in psychiatry]. Ann Med Psychol (Paris). 1972 Dec;2(5):708-18. French. PubMed PMID: 4576211.

12: Utting HJ, Pleuvry BJ. Benzoctamine-a study of the respiratory effects of oral doses in human volunteers and interactions with morphine in mice. Br J Anaesth. 1975 Sep;47(9):987-92. PubMed PMID: 1103919.

13: Coelle EF, Osborne NN, Neuhoff V, Sontag KH. [The influence of benzoctamine on dopamine and norepinephrine contents in substantia nigra and on the muscle stretch reflex of the cat (author's transl)]. Arzneimittelforschung. 1979;29(10):1556-60. German. PubMed PMID: 42412.

14: Stäubli W, Schweizer W, Suter J, Hess R. Ultrastructural and biochemical study of the action of benzoctamine and maprotiline on the rat liver. Agents Actions. 1974 Dec;4(5):391-403. PubMed PMID: 4480448.

15: Tolksdorf W, Rohowsky R, Eberwein S. [The effects of flunitrazepam and benzoctamine on the blood gases during translumbar aortography in spinal analgesia (author's transl)]. Anasth Intensivther Notfallmed. 1980 Oct;15(5):407-11. German. PubMed PMID: 6109465.

16: Pérez de Francisco C, Castilla J, Lecona R, Huitrón G. [Benzoctamine in geriatric psychocardiology]. Prensa Med Mex. 1972 Sep-Oct;37(9):385-9. Spanish. PubMed PMID: 4679191.

17: Teja JS, Shah DK, Wig NN. Benzoctamine (Tacitin) versus placebo: a double-blind cross over study in anxiety neurotics. Curr Ther Res Clin Exp. 1975 Aug;18(2):354-8. PubMed PMID: 809248.

18: Martin A, Masson JM, Quentin JC, Verrier JP. [Benzoctamine in psychiatry (30 cases)]. Ann Med Psychol (Paris). 1972 Jul-Aug;2(2):282-6. French. PubMed PMID: 4678495.

19: McLeod WR. A comparison of diazepam, benzoctamine, and placebo in anxiety states. Curr Ther Res Clin Exp. 1972 May;14(5):239-45. PubMed PMID: 4623974.

20: Jaques R, Helfer H. The antinociceptive action of a novel anxiolytic and tensiolytic drug (benzoctamine) in two different writhing syndromes. Pharmacology. 1971;6(1):35-40. PubMed PMID: 5171843.